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Review
. 2021 Jun;41(2):309-324.
doi: 10.1016/j.cll.2021.03.009.

Bringing Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging to the Clinics

Sankha S Basu  1 , Nathalie Y R Agar  2
Affiliations
Review

Bringing Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging to the Clinics

Sankha S Basu et al. Clin Lab Med. 2021 Jun.

Abstract

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is an emerging analytical technique that promises to change tissue-based diagnostics. This article provides a brief introduction to MALDI MSI as well as clinical diagnostic workflows and opportunities to apply this powerful approach. It describes various MALDI MSI applications, from more clinically mature applications such as cancer to emerging applications such as infectious diseases and drug distribution. In addition, it discusses the analytical considerations that need to be considered when bringing these approaches to different diagnostic problems and settings.

Keywords: Cancer; Clinical; Drug distribution; Infectious disease; MALDI; Mass spectrometry imaging.

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