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Case Reports
. 2021 Jul-Aug;96(4):442-446.
doi: 10.1016/j.abd.2020.06.025. Epub 2021 May 18.

Blastoid mantle cell lymphoma: cutaneous infiltration

Mariana Righetto de Ré  1 , Flávia de Oliveira Valentim  1 , Mariangela Esther Alencar Marques  1 , Silvio Alencar Marques  2
Affiliations
Case Reports

Blastoid mantle cell lymphoma: cutaneous infiltration

Mariana Righetto de Ré et al. An Bras Dermatol. 2021 Jul-Aug.

Abstract

Mantle cell lymphoma is an aggressive B-cell, non-Hodgkin's lymphoma, with lymph node or extranodal origin, and a mean survival of three to five years. Skin involvement is rare, secondary and indicates neoplasia dissemination. The authors report a case of a female patient, 69 years old, diagnosed previously, after lymph node and bone marrow biopsy. She was undergoing the second chemotherapy regimen when she showed infiltrated plaque-like lesions, nodules and tumors on the trunk and thigh root. Histopathology and immunohistochemistry demonstrated cutaneous infiltration of the blastoid lymphoma.

Keywords: B-lymphocytes; Lymphoma; Pathology; Skin neoplasms.

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Figures

Figure 1
Figure 1
Cutaneous mantle-cell lymphoma. Infiltrated purplish erythematous papules and plaques, located on the upper thorax.
Figure 2
Figure 2
Infiltrated plaque in the scapular region and infiltrated papules and plaque on the breast and sternal regions.
Figure 3
Figure 3
Cutaneous mantle-cell lymphoma. Erythematous-brownish nodules and tumors on the right inguinal crural region.
Figure 4
Figure 4
Cutaneous mantle-cell lymphoma. (A) Tumor infiltration in the dermis by small and medium-sized lymphocytes (Hematoxylin & eosin, ×40). (B) Higher magnification showing the Grenz zone isolating the infiltrate from the epidermis (Hematoxylin & eosin, ×100).
Figure 5
Figure 5
Detail of the neoplastic infiltration with an accumulation of blastoid cells, with large, irregular nuclei and scarce cytoplasm. (Hematoxylin & eosin, ×200).
Figure 6
Figure 6
Cutaneous mantle-cell lymphoma. Immunohistochemistry staining: (A) CD20, (B) Cyclin-D1 and (C) PAX5.
See this image and copyright information in PMC

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