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Randomized Controlled Trial
. 2021 Aug;58(8):e13843.
doi: 10.1111/psyp.13843. Epub 2021 May 22.

Sedentary time is related to deficits in response inhibition among adults with overweight and obesity: An accelerometry and event-related brain potentials study

Dominika M Pindus  1   2   3 , Caitlyn G Edwards  4 , Anne M Walk  5 , Ginger Reeser  1 , Nicholas A Burd  1   6 , Hannah D Holscher  1   6   7 , Naiman A Khan  1   3   6   7
Affiliations
Randomized Controlled Trial

Sedentary time is related to deficits in response inhibition among adults with overweight and obesity: An accelerometry and event-related brain potentials study

Dominika M Pindus et al. Psychophysiology. 2021 Aug.

Abstract

Excessive sedentariness has been related to poorer cognitive control in adults. Sedentariness may compound obesity-related impairments in response inhibition, but its relationship to response inhibition remains poorly understood. This study investigated the relationship between accelerometer-measured sedentary time (ST, min/day), performance on the Oddball and NoGo tasks, N2 and P3-ERP indices of response inhibition and attentional control in 80 adults with overweight and obesity (55 females, Mage = 35.2 ± 5.8 years, BMI = 32.8 ± 5.3 kg/m2 ). ST was not related to performance on the Oddball task. However, more sedentary adults had larger P3b amplitude to targets. Higher ST was also related to increased attentional resource allocation during NoGo target and nontarget trials as indicated by higher P3b amplitudes across centroparietal sites (C1, Cz, C2, CP1, CPz, CP2; ps ≤ .03). ST was negatively indirectly related to target accuracy on NoGo trials through its association with faster response times to nontargets (95% percentile bootstrap CI for a standardized effect: -0.182, -0.014). ST was not related to N2 amplitude on either Oddball or NoGo target trials. Adjustment for moderate-to-vigorous physical activity (MVPA; all models), age (models with P3b NoGo target amplitude, N2 NoGo target amplitude and latency), and % fat mass (models with target NoGo accuracy and N2 NoGo target amplitude) did not modulate behavioral findings. MVPA did not significantly predict P3b amplitude. Our results suggest suboptimal response inhibition due to trading accuracy for speed and despite the upregulation of attentional resources among more sedentary adults with overweight and obesity.

Keywords: EEG; Go/NoGo; P300; obesity; response inhibition; sedentary time.

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References

REFERENCES

    1. 2018 Physical Activity Guidelines Advisory Committee. (2018). 2018 Physical Activity Guidelines Advisory Committee scientific report. U.S. Department of Health and Human Services. https://health.gov/paguidelines/second-edition/report/pdf/PAG_Advisory_C...
    1. Aichert, D. S., Wöstmann, N. M., Costa, A., Macare, C., Wenig, J. R., Möller, H.-J., Rubia, K., & Ettinger, U. (2012). Associations between trait impulsivity and prepotent response inhibition. Journal of Clinical and Experimental Neuropsychology, 34(10), 1016-1032. https://doi.org/10.1080/13803395.2012.706261
    1. Aron, A. R. (2011). From reactive to proactive and selective control: Developing a richer model for stopping inappropriate responses. Biological Psychiatry, 69(12), e55-e68. https://doi.org/10.1016/j.biopsych.2010.07.024
    1. Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2014). Inhibition and the right inferior frontal cortex: One decade on. Trends in Cognitive Sciences, 18(4), 177-185. https://doi.org/10.1016/j.tics.2013.12.003
    1. Bakrania, K., Edwardson, C. L., Khunti, K., Bandelow, S., Davies, M. J., & Yates, T. (2018). Associations between sedentary behaviors and cognitive function: Cross-sectional and prospective findings from the UK Biobank. American Journal of Epidemiology, 187(3), 441-454. https://doi.org/10.1093/aje/kwx273

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