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Observational Study
. 2021 Sep:236:297-300.e1.
doi: 10.1016/j.jpeds.2021.05.037. Epub 2021 May 19.

Multicenter Validation of the Neonatal Sequential Organ Failure Assessment Score for Prognosis in the Neonatal Intensive Care Unit

James L Wynn  1 , Anoop Mayampurath  2 , Kyle Carey  2 , Susan Slattery  3 , Bree Andrews  2 , L Nelson Sanchez-Pinto  3
Affiliations
Observational Study

Multicenter Validation of the Neonatal Sequential Organ Failure Assessment Score for Prognosis in the Neonatal Intensive Care Unit

James L Wynn et al. J Pediatr. 2021 Sep.

Abstract

Infants in the neonatal intensive care unit are at risk of life-threatening organ dysfunction, but few objective tools with utility exist. In a multicenter cohort of 20 152 infants, we show the neonatal sequential organ failure assessment score had good-to-excellent discrimination of mortality across centers, birth weights, and time points after admission.

Keywords: electronic health records; health resources; mortality; neonate; organ dysfunction.

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Conflict of interest statement

Conflict of interest statement: No author has a commercial interest or patent on this work. JLW has served as a paid consultant for Evolve Biosystems. BA is an equity partner in Preeme+You, a social benefit corporation that develops bedside technology to help parents at the NICU bedside with a goal to minimize health disparities. No funding sources had any role in this study. All other authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.. Distribution of the maximum nSOFA score and associated 28-day mortality in the three NICUs.
Across the three sites, 61% of patients had a maximum nSOFA of 0 by day 28, and these had an associated 28-day mortality of 0.1% (not pictured). The whiskers in the top panel represent the 95% confidence interval for 28-day mortality. Abbreviations: nSOFA, neonatal sequential organ failure assessment; NICU, neonatal intensive care unit.
See this image and copyright information in PMC

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