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. 2021 May 22;16(1):140.
doi: 10.1186/s13019-021-01524-9.

Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Fuwen Huang  1 , Jingting Mai  2 , Jingwei Chen  2 , Yinying He  1 , Xiaojun Chen  3
Affiliations

Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Fuwen Huang et al. J Cardiothorac Surg. .

Abstract

The myocardial infarction is the main cause of morbidity and mortality in cardiovascular diseases around the world. Although the timely and complete reperfusion via Percutaneous Coronary Intervention (PCI) or thrombolysis have distinctly decreased the mortality of myocardial infarction, reperfusion itself may lead to supererogatory irreversible myocardial injury and heart function disorders, namely ischemia-reperfusion (I/R) injury. Extensive studies have indicated that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play important roles in the progress of myocardial I/R injury, which is closely correlative with cardiomyocytes autophagy. Moreover, autophagy plays an important role in maintaining homeostasis and protecting cells in the myocardial ischemia reperfusion and cardiomyocyte hypoxia-reoxygenation (H/R) progress. In this review, we first introduced the biogenesis and functions of ncRNAs, and subsequently summarized the roles and relevant molecular mechanisms of ncRNAs regulating autophagy in myocardial I/R injury. We hope that this review in addition to develop a better understanding of the physiological and pathological roles of ncRNAs, can also lay a foundation for the therapies of myocardial I/R injury, and even for other related cardiovascular diseases.

Keywords: Autophagy; Molecular mechanisms; Myocardial ischemia-reperfusion-injury; Non-coding RNAs (ncRNAs).

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Conflict of interest statement

The authors declare that they have has no conflict/competing of interest.

Figures

Fig. 1
Fig. 1
A diagram showing regulation of autophagy pathway by ncRNAs after myocardial ischemia-reperfusion injury. The diagram exhibited the various ncRNAs and their targets that are involved in the modulation of autophagy during myocardial ischemia-reperfusion injury. The listed targets included LC3-II, p62, Beclin-1, ULK1, Atg3, Atg5, Atg7, Atg12, Atg13, PI3K/AKT signaling pathway. MiRNAs show as in black in the yellow box, and lncRNAs in green
See this image and copyright information in PMC

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