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Review
. 2021 May;48(5):4721-4731.
doi: 10.1007/s11033-021-06408-8. Epub 2021 May 22.

Mitochondrial remodelling-a vicious cycle in diabetic complications

Bhoomika Sherkhane  1 , Gundu Chayanika  1 , Anika Sood  1 , Dharmendra Kumar Khatri  2 , Shashi Bala Singh  3
Affiliations
Review

Mitochondrial remodelling-a vicious cycle in diabetic complications

Bhoomika Sherkhane et al. Mol Biol Rep. 2021 May.

Abstract

Diabetes mellitus (DM) is a chronic, metabolic condition characterized by excessive blood glucose that causes perturbations in physiological functioning of almost all the organs of human body. This devastating metabolic disease has its implications in cognitive decline, heart damage, renal, retinal and neuronal complications that severely affects quality of life and associated with decreased life expectancy. Mitochondria possess adaptive mechanisms to meet the cellular energy demand and combat cellular stress. In recent years mitochondrial homeostasis has been point of focus where several mechanisms regulating mitochondrial health and function are evaluated. Mitochondrial dynamics plays crucial role in maintaining healthy mitochondria in cell under physiological as well as stress condition. Mitochondrial dynamics and corresponding regulating mechanisms have been implicated in progression of metabolic disorders including diabetes and its complications. In current review we have discussed about role of mitochondrial dynamics under physiological and pathological conditions. Also, modulation of mitochondrial fission and fusion in diabetic complications are described. The available literature supports mitochondrial remodelling as reliable target for diabetic complications.

Keywords: Diabetic complications; Mitochondria; Mitochondrial dynamics; Mitochondrial fission; Mitochondrial fusion; Mitochondrial morphology.

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