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. 2021 May 24;3(1):29.
doi: 10.1186/s42466-021-00126-z.

N,N-Dimethylglycine in patients with progressive multiple sclerosis: result of a pilot double-blind, placebo, controlled randomized clinical trial

Thomas Wolfsegger  1 , Klaus Böck  2 , Wolfgang Schimetta  3 , Tim J von Oertzen  2 , Hamid Assar  2
Affiliations

N,N-Dimethylglycine in patients with progressive multiple sclerosis: result of a pilot double-blind, placebo, controlled randomized clinical trial

Thomas Wolfsegger et al. Neurol Res Pract. .

Abstract

Oral administration of N,N-Dimethylglycine (DMG), a tertiary amino acid, presumably enhances oxygen utilization by tissue and complex with free radicals. Beneficial effects are improved endurance performance and reduction fatigue in humans and animals. This pilot study reports the results over a one-year double-blind, placebo-controlled trial of DMG in 30 randomized patients with progressive multiple sclerosis. No treatment effects were found between the placebo group and the DMG group for disability, fatigue, cognitive, or gait parameters.

Keywords: Dietary supplement; Mobility; Multiple sclerosis; N,N-Dimethylglycine; Nutrition therapy.

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Conflict of interest statement

The authors declare that they have no competing interests.

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