Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2022 Jun 1;29(6):881-893.
doi: 10.5551/jat.62832. Epub 2021 May 22.

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Ariko Umezawa  1 , Chizuko Maruyama  1   2 , Yasuhiro Endo  3 , Yumiko Suenaga  3 , Yuri Shijo  1 , Noriko Kameyama  2 , Aisa Sato  1 , Ai Nishitani  4 , Makoto Ayaori  5 , Masako Waki  6 , Tamio Teramoto  4   7 , Katsunori Ikewaki  3   5
Affiliations
Randomized Controlled Trial

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Ariko Umezawa et al. J Atheroscler Thromb. .

Abstract

Aim: Improving cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) has been regarded as a novel target for preventing cardiovascular disease. HDL reportedly has antioxidant properties which may contribute to its functions. We investigated changes in CEC with intake of the Japan Diet (JD) recommended by the Japan Atherosclerosis Society and the relationship of these changes to serum antioxidant concentrations.

Methods: A randomized parallel controlled clinical trial on JD intake was performed in Japanese patients with dyslipidemia. Ninety-eight participants were randomly divided into the JD (n=49) or the partial JD (PJD) (n=49) group. Nutrition education, based on each diet at baseline and at 3 months, was provided and the participants were followed up for 6 months.

Results: Mean CEC was 1.05 in total and correlated positively with HDL-cholesterol (p＜0.001) at baseline. CEC did not change while oxygen radical absorbance capacity (ORAC) was decreased in both groups (p＜0.001). Although serum total carotenoid increased in both groups, serum α-tocopherol decreased in the JD group as compared to the PJD group (p＜0.05). CEC correlated positively with HDL ORAC at baseline (p=0.021) and with serum total carotenoid at 3 and 6 months (p=0.005, 0.035). Changes in CEC correlated positively with changes in HDL ORAC at 3 months and serum total tocopherol at 3 and 6 months (p＜0.001).

Conclusion: CEC was not changed by JD education in Japanese patients with dyslipidemia who already had normal CEC at baseline. CEC was suggested to be positively associated with serum α- and γ-tocopherol and HDL ORAC.

Keywords: Carotenoid; Cholesterol efflux capacity; Diet; Oxygen radical absorbance capacity; Tocopherol.

PubMed Disclaimer

Figures

Fig.1. Correlation between changes in CEC and serum α and γ- tocopherol concentrations at 3 and 6 months
Fig.1. Correlation between changes in CEC and serum α and γ- tocopherol concentrations at 3 and 6 months
n=98, Correlation between changes in CEC and (A) serum α-tocopherol and (B) γ-tocopherol. The statistical significances of correlations were assessed using the non-parametric Spearman’s ranked test. Changes in CEC correlated positively with changes in serum α and γ-tocopherol.
See this image and copyright information in PMC

References

    1. Wilson PW, Abbott RD, and Castelli WP: High density lipoprotein cholesterol and mortality. The Framingham Heart Study. Arteriosclerosis, 1988; 8: 737-741 - PubMed
    1. Talbot CPJ, Plat J, Ritsch A, and Mensink RP: Determinants of cholesterol efflux capacity in humans. Prog Lipid Res, 2018; 69: 21-32 - PubMed
    1. van Capelleveen JC, Brewer HB, Kastelein JJ, and Hovingh GK: Novel therapies focused on the high-density lipoprotein particle. Circ Res, 2014; 114: 193-204 - PubMed
    1. de Goma EM, de Goma RL, and Rader DJ: Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches. J Am Coll Cardiol, 2008; 51: 2199-2211 - PMC - PubMed
    1. Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky RL, Mohler ER, Rothblat GH, and Rader DJ: Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med, 2011; 364: 127-135 - PMC - PubMed

Publication types