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. 2021;57(4):383-409.
doi: 10.1007/s10593-021-02916-4. Epub 2021 May 15.

Pyrimido[1,2- a]benzimidazoles: synthesis and perspective of their pharmacological use

Victor V Fedotov  1 , Vladimir L Rusinov  1   2 , Evgeny N Ulomsky  1   2 , Evgeny M Mukhin  1 , Evgeny B Gorbunov  2 , Oleg N Chupakhin  1   2
Affiliations

Pyrimido[1,2- a]benzimidazoles: synthesis and perspective of their pharmacological use

Victor V Fedotov et al. Chem Heterocycl Compd (N Y). 2021.

Abstract

The review presents data on the synthesis as well as studies of biological activity of new derivatives of pyrimido[1,2-a]benzimidazoles published over the last decade. The bibliography of the review includes 136 sources.

Keywords: 2-aminobenzimidazole; heterocyclization; multicomponent reactions; polynitrogen-containing heteroarenes; pyrimido[1,2-a]benzimidazoles.

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Figures

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Azoloazine-based antiviral drugs.
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The drugs based on benzimidazole.
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Ionic liquids used in MCR synthesis of pyrimido-[1,2-a]benzimidazoles 140.
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The structure of solvent 146.
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The structures of catalysts 175 and 176.
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See this image and copyright information in PMC

References

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    1. Al Bujuq, N. Synthesis2020, 3735.
    1. Rusinov, V. L.; Charushin, V. N.; Chupakhin, O. N. Russ. Chem. Bull., Int. Ed.2018, 67, 573. [Izv. Akad. Nauk, Ser. Khim.2018, 573.]

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