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Case Reports
. 2021 Mar 28;9(5):e03925.
doi: 10.1002/ccr3.3925. eCollection 2021 May.

Statin-associated necrotizing autoimmune myopathy with concurrent myasthenia gravis

Emma Frasson  1 , Marco Simonetto  1 , Laura Bertolasi  2 , Giorgio Caneve  1 , Cristina Vilotti  1 , Giampietro Ruzza  1 , Anna Perelli  1 , Maria Grazia Piccinno  1 , Salvatore Monaco  2
Affiliations
Case Reports

Statin-associated necrotizing autoimmune myopathy with concurrent myasthenia gravis

Emma Frasson et al. Clin Case Rep. .

Abstract

Statin treatment has been associated with necrotizing autoimmune myopathy and has been linked to myasthenia gravis. We present an unprecedented clinical challenge with both disorders occurring in a patient treated with statins few months earlier.

Keywords: autoimmune disease; myasthenia gravis; necrotizing autoimmune myopathy; statins.

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Conflict of interest statement

None of the authors has potential conflicts of interest to be disclosed.

Figures

FIGURE 1
FIGURE 1
Muscle MRI of lower limbs. Coronal T1‐weighted images (A) reveal muscle atrophy and hyperintensity reflecting connective tissue and fatty replacement (arrows). Coronal short‐tau inversion recovery (STIR) sequences (B) show edema and asymmetrically increased signals in muscle compartments (arrows). Axial T2‐weighted sequences show atrophy in proximal (C) and in the distal (D) thigh muscles. (semimembranosus = SM). PEC, denotes pectineus, PSOAS, ileopsoas, ADB, adductor brevis, OE, obturator externus, and OI, obturator internus
See this image and copyright information in PMC

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