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. 2021 May 7:8:621389.
doi: 10.3389/fcvm.2021.621389. eCollection 2021.

Diagnostic Performance of CMR, SPECT, and PET Imaging for the Identification of Coronary Artery Disease: A Meta-Analysis

Jianfeng Xu  1   2 , Fei Cai  1   2 , Changran Geng  1 , Zheng Wang  2 , Xiaobin Tang  1
Affiliations

Diagnostic Performance of CMR, SPECT, and PET Imaging for the Identification of Coronary Artery Disease: A Meta-Analysis

Jianfeng Xu et al. Front Cardiovasc Med. .

Abstract

Background: Myocardial perfusion imaging modalities, such as cardiac magnetic resonance (CMR), single-photon emission computed tomography (SPECT), and positron emission tomography (PET), are well-established non-invasive diagnostic methods to detect hemodynamically significant coronary artery disease (CAD). The aim of this meta-analysis is to compare CMR, SPECT, and PET in the diagnosis of CAD and to provide evidence for further research and clinical decision-making. Methods: PubMed, Web of Science, EMBASE, and Cochrane Library were searched. Studies that used CMR, SPECT, and/or PET for the diagnosis of CAD were included. Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio with their respective 95% confidence interval, and the area under the summary receiver operating characteristic (SROC) curve were calculated. Results: A total of 203 articles were identified for inclusion in this meta-analysis. The pooled sensitivity values of CMR, SPECT, and PET were 0.86, 0.83, and 0.85, respectively. Their respective overall specificity values were 0.83, 0.77, and 0.86. Results in subgroup analysis of the performance of SPECT with 201Tl showed the highest pooled sensitivity [0.85 (0.82, 0.88)] and specificity [0.80 (0.75, 0.83)]. 99mTc-tetrofosmin had the lowest sensitivity [0.76 (0.67, 0.82)]. In the subgroup analysis of PET tracers, results indicated that 13N had the lowest pooled sensitivity [0.83 (0.74, 0.89)], and the specificity was the highest [0.91 (0.81, 0.96)]. Conclusion: Our meta-analysis indicates that CMR and PET present better diagnostic performance for the detection of CAD as compared with SPECT.

Keywords: coronary artery disease; diagnostic performance; meta-analysis; myocardial perfusion imaging; non-invasive modality.

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Conflict of interest statement

JX and ZW were employed by the company JYAMS PET Research and Development Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Search results and flowchart of the meta-analysis.
Figure 2
Figure 2
Risk of bias and applicability concerns on the QUADAS-2 tool of the included studies.
Figure 3
Figure 3
SROC curves for diagnostic performance of CMR, SPECT, and PET. (A) SROC curve for diagnostic performance of CMR. (B) SROC curves for diagnostic performance of SPECT. (C) SROC curves for diagnostic performance of PET.
See this image and copyright information in PMC

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