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Review
. 2021 May 7:8:659628.
doi: 10.3389/fcvm.2021.659628. eCollection 2021.

Role of N6-Methyladenosine RNA Modification in Cardiovascular Disease

Dandan Song  1   2 , Jianhua Hou  3 , Junduo Wu  4 , Junnan Wang  4
Affiliations
Review

Role of N6-Methyladenosine RNA Modification in Cardiovascular Disease

Dandan Song et al. Front Cardiovasc Med. .

Abstract

Despite treatments being improved and many risk factors being identified, cardiovascular disease (CVD) is still a leading cause of mortality and disability worldwide. N6-methyladenosine (m6A) is the most common, abundant, and conserved internal modification in RNAs and plays an important role in the development of CVD. Many studies have shown that aabnormal m6A modifications of coding RNAs are involved in the development of CVD. In addition, non-coding RNAs (ncRNAs) exert post-transcriptional regulation in many diseases including CVD. Although ncRNAs have also been found to be modified by m6A, the studies on m6A modifications of ncRNAs in CVD are currently lacking. In this review, we summarized the recent progress in understanding m6A modifications in the context of coding RNAs and ncRNAs, as well as their regulatory roles in CVD.

Keywords: CVD; M6A; mRNAs; modification; non-coding RNAs.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of the deposition of m6A modification on mRNA and non-coding RNAs. m6A writers, erasers, and readers regulate the deposition of m6A modification and affect the translocation, translation, stability, degradation, and structure of RNA.
Figure 2
Figure 2
Regulation of m6A RNA modification in CVD. CVD risk factors can result in deregulated m6A deposition on mRNA, miRNA, lnc RNA, circ RNA, which are known to play a role in the development of cardiac and vascular disease.
See this image and copyright information in PMC

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