Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988;226(3):273-6.
doi: 10.1007/BF02181195.

Side effects in excimer corneal surgery. DNA damage as a result of 193 nm excimer laser radiation

T Seiler  1 , T Bende, K Winckler, J Wollensak
Affiliations

Side effects in excimer corneal surgery. DNA damage as a result of 193 nm excimer laser radiation

T Seiler et al. Graefes Arch Clin Exp Ophthalmol. 1988.

Abstract

UV radiation is known to cause actinic damage to the DNA. Excimer laser light, possibly used for keratorefractive surgery, should not produce this damage, as the penetration depth is far less than the diameter of a cell. However, photoreactivation experiments with yeast cells show a significant amount of DNA repair after excimer irradiation. The zone of influence of a small slitlike exposure has a diameter of 2 cm. Consequently, the limbus, the critical location of epithelial neoplasia, always lies within the sphere of actinic damage. Radiation damage is induced by secondary radiation rather than by direct interaction.

PubMed Disclaimer

References

    1. Am J Ophthalmol. 1983 Dec;96(6):710-5 - PubMed
    1. Photochem Photobiol. 1981 Oct;34(4):461-4 - PubMed
    1. Photochem Photobiol. 1981 Feb;33(2):257-60 - PubMed
    1. Ophthalmology. 1985 Jun;92(6):749-58 - PubMed
    1. Biophys J. 1975 May;15(5):435-40 - PubMed