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. 2021 Sep;76(9):2910-2913.
doi: 10.1111/all.14953. Epub 2021 Jun 7.

Long-term disruption of cytokine signalling networks is evident in patients who required hospitalization for SARS-CoV-2 infection

Sinead Ahearn-Ford  1 , Nonhlanhla Lunjani  1 , Brian McSharry  1   2 , John MacSharry  1   2   3 , Liam Fanning  1   3 , Gerard Murphy  4 , Cormac Everard  4 , Aoife Barry  4 , Aimee McGreal  4 , Sultan Mohamed Al Lawati  4 , Susan Lapthorne  4 , Colin Sherlock  4 , Anna McKeogh  4 , Arthur Jackson  4 , Eamonn Faller  4 , Mary Horgan  3   4 , Corinna Sadlier  4 , Liam O'Mahony  1   2   3
Affiliations

Long-term disruption of cytokine signalling networks is evident in patients who required hospitalization for SARS-CoV-2 infection

Sinead Ahearn-Ford et al. Allergy. 2021 Sep.
No abstract available

Keywords: COVID; SARS-CoV-2; inflammation; interleukins.

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Conflict of interest statement

Dr. O'Mahony reports grants from Science Foundation Ireland, during the conduct of the study; grants from GSK; and personal fees from PrecisionBiotics, outside the submitted work. None of the other authors report any conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Proinflammatory and endothelial mediators in post‐COVID patients. Proinflammatory mediators (A) and angiogenesis‐associated factors (B) are elevated in sera from patients 3–9 months post‐COVID hospital discharge compared to levels in sera from healthy controls. Results are illustrated on a log scale, and the mean ± standard error is indicated for each group. Depending on the data distribution, unpaired t‐tests or Mann‐Whitney tests were used to determine statistical significance. *p < .05; **p < .01; ***p < .001; and ****p < .0001
FIGURE 2
FIGURE 2
TH2 and TH17 cytokines in post‐COVID patients. Sera from patients 3–9 months post‐COVID hospital discharge are significantly different compared to healthy controls for TH2 cytokines (A) and TH17 cytokines (B). Results are illustrated on a log scale, and the mean ± standard error is indicated for each group. Depending on the data distribution, unpaired t‐tests or Mann‐Whitney tests were used to determine statistical significance. *p < .05; **p < .01; and ***p < .001
See this image and copyright information in PMC

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