Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jun 22;144(5):1284-1285.
doi: 10.1093/brain/awab149.

Microglial activation and blood-brain barrier leakage: chicken and egg?

Affiliations
Comment

Microglial activation and blood-brain barrier leakage: chicken and egg?

Paul Edison. Brain. .

Abstract

This scientific commentary refers to ‘Microglial activation and blood–brain barrier permeability in cerebral small vessel disease’ by Walsh et al. (doi:10.1093/brain/awab003).

PubMed Disclaimer

Comment on

References

    1. Simpson JE, Ince PG, Higham CE, et al.; MRC Cognitive Function and Ageing Neuropathology Study Group. Microglial activation in white matter lesions and nonlesional white matter of ageing brains. Neuropathol Appl Neurobiol. 2007;33(6):670–683. - PubMed
    1. Noz MP, Ter Telgte A, Wiegertjes K, et al. Trained immunity characteristics are associated with progressive cerebral small vessel disease. Stroke. 2018;49(12):2910–2917. - PubMed
    1. Arba F, Leigh R, Inzitari D, et al.; STIR/VISTA Imaging Collaboration. Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke. Neurology. 2017;89(21):2143–2150. - PMC - PubMed
    1. Kuntz M, Mysiorek C, Petrault O, et al. Stroke-induced brain parenchymal injury drives blood-brain barrier early leakage kinetics: A combined in vivo/in vitro study. J Cereb Blood Flow Metab. 2014;34(1):95–107. - PMC - PubMed
    1. Zhang CE, Wong SM, Uiterwijk R, et al. Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging. Brain Imaging Behav. 2019;13(2):389–395. - PMC - PubMed