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. 2021 Aug;37(8):2531-2537.
doi: 10.1007/s00381-021-05189-6. Epub 2021 May 24.

Characteristics of growth disturbances in patients with intracranial germinomas of different origins

Bo Li #  1   2 , Jiayi Wang #  1 , Jiongxian Yang  3 , Yanong Li  1 , Yanwei Liu  1 , Shuai Liu  1 , Xiaoguang Qiu  4   5
Affiliations

Characteristics of growth disturbances in patients with intracranial germinomas of different origins

Bo Li et al. Childs Nerv Syst. 2021 Aug.

Abstract

Purpose: To explore the characteristics of growth disturbance in patients with intracranial germinoma with different origins.

Methods: Clinical data of 151 patients with single-origin germinomas were studied retrospectively. Z-score of height (ZSOH) at both diagnosis and the last follow-up was calculated using the WHO AnthroPlus software. Linear regression was used to analyse the correlation between the absolute change in ZSOH (|ZSOH last follow-up - ZSOH diagnosis|) and clinical factors.

Results: The mean ZSOH decreased significantly in every origin subgroup at the last follow-up. In patients with sellar germinoma (n = 62), the mean ZSOH values at both diagnosis and the last follow-up were significantly lower than those in patients with pineal (n = 30) (p < 0.001) or basal ganglia germinomas (n = 59) (p < 0.001), respectively. In patients with basal ganglia germinoma, the mean absolute change in ZSOH decreased significantly compared to that in the patients with sellar (p = 0.006) or pineal germinomas (p = 0.04). Linear analysis revealed that sex (male vs female; p = 0.003) and age at diagnosis (≤10 years vs >10 years; p = 0.026) had negative correlations, while radiation dose at the hypothalamic-pituitary axis (HPA) (≤40 Gy vs >40 Gy; p = 0.085) had a marginally positive correlation, with absolute change in ZSOH.

Conclusions: Patients with germinoma experienced growth retardation after treatments. The growth disturbance was consistent and more severe in patients with germinoma of sellar origin, while the greatest aggravation was observed in patients with germinoma of basal ganglia origin. Decreasing radiation dose to the HPA may minimize the negative impact of radiotherapy on growth.

Keywords: Germinoma; Growth height; Hypothalamic-pituitary axis; Radiation.

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References

    1. Murray MJ, Bartels U, Nishikawa R, Fangusaro J, Matsutani M, Nicholson JC (2015) Consensus on the management of intracranial germ-cell tumours. Lancet Oncol 16:e470–e477 - DOI
    1. Lee SH, Jung KW, Ha J, Oh CM, Kim H, Park HJ, Yoo H, Won YJ (2017) Nationwide population-based incidence and survival rates of malignant central nervous system germ cell tumors in Korea, 2005–2012. Cancer Res Treat 49:494–501 - DOI
    1. Murray MJ, Horan G, Lowis S, Nicholson JC (2013) Highlights from the Third International Central Nervous System Germ Cell Tumour symposium: laying the foundations for future consensus. Ecancermedicalscience 7:333 - DOI
    1. Gao Y, Jiang J, Liu Q (2014) Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience. Int J Clin Exp Pathol 7:6965–6972 - PubMed - PMC
    1. Li B, Feng J, Chen L, Li Y, Wang J, Lv W, Li Y, Liu Y, Liu S, Luo S, Qiu X (2021) Relapse pattern and quality of life in patients with localized basal ganglia germinoma receiving focal radiotherapy, whole-brain radiotherapy, or craniospinal irradiation. Radiother Oncol 158:90–96 - DOI

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