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Comment
. 2021 Aug;100(2):479-480.
doi: 10.1016/j.kint.2021.05.013. Epub 2021 May 23.

Evidence of cell-mediated immune response in kidney transplants with a negative mRNA vaccine antibody response

Sebastian Dolff  1 , Baotong Zhou  2 , Johannes Korth  2 , De Luo  2 , Yang Dai  2 , Michael Jahn  2 , Oliver Dorsch  3 , Olympia Evdoxia Anastasiou  4 , Oliver Witzke  1 , Andreas Kribben  2 , Benjamin Wilde  5
Affiliations
Comment

Evidence of cell-mediated immune response in kidney transplants with a negative mRNA vaccine antibody response

Sebastian Dolff et al. Kidney Int. 2021 Aug.
No abstract available

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Figures

Figure 1
Figure 1
S-protein–reactive T-helper cells in renal transplant patients after vaccination. (a) Peripheral blood mononuclear cells were freshly isolated from whole blood and cultured for 16 hours in the presence of overlapping peptide pools for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and brefeldin A. T cells coexpressing CD154 and CD137 were defined as S-protein–specific. The cytokine profile of S-protein–specific T cells was characterized, and interleukin-2 (IL-2)/interferon-γ (IFN-γ) expression was determined. (b) In all 7 patients, S-protein–specific T-helper cells were detectable. (c) S-protein–specific T-helper cells produced IL-2 and IFN-γ. Pos, positive.
See this image and copyright information in PMC

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References

    1. Benotmane I., Gautier-Vargas G., Cognard N. Low immunization rates among kidney transplant recipients who received 2 doses of the mRNA-1273 SARS-CoV-2 vaccine. Kidney Int. 2021;99:1498–1500. - PMC - PubMed
    1. Korth J., Jahn M., Dorsch O. Impaired humoral response in renal transplant recipients to SARS-CoV-2 vaccination with BNT162b2 (Pfizer-BioNTech) Viruses. 2021;13:756. - PMC - PubMed
    1. Sattler A., Angermair S., Stockmann H. SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition. J Clin Invest. 2020;130:6477–6489. - PMC - PubMed