doi: 10.1159/000234588.
Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP)
Affiliations
- PMID: 3403044
- DOI: 10.1159/000234588
Item in Clipboard
Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP)
Int Arch Allergy Appl Immunol.
1988.
Abstract
An acute pulmonary response was induced in guinea pigs and hamsters by inhalation of bacterial endotoxin in the form of a purified lipopolysaccharide (LPS). Pretreatment with the platelet-activating factor (PAF) antagonist, 48740 RP, inhibited damage to endothelial cells, decreased vascular permeability and the number of neutrophils in the airways 24 h after exposure to LPS. The increase in the number of platelets in the airways caused by endotoxin was not affected. The results suggest that PAF modulates early inflammation after endotoxin inhalation.
Similar articles
-
The role of platelet-activating factor in the pulmonary response to inhaled bacterial endotoxin.Am Rev Respir Dis. 1991 Jul;144(1):167-72. doi: 10.1164/ajrccm/144.1.167. Am Rev Respir Dis. 1991. PMID: 2064124
-
Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor.Shock. 1995 Nov;4(5):368-72. doi: 10.1097/00024382-199511000-00010. Shock. 1995. PMID: 8595525
-
The platelet activating factor receptor antagonist, RP 59227, blocks platelet activating factor receptors mediating liberation of reactive oxygen species in guinea pig macrophages and human polymorphonuclear leukocytes.J Pharmacol Exp Ther. 1991 Aug;258(2):567-75. J Pharmacol Exp Ther. 1991. PMID: 1650834
-
[PAF-acether antagonistic pyrrolo[1,2-c]thiazoles: from RP 48740 to RP 59227].J Pharm Belg. 1990 May-Jun;45(3):219-23. J Pharm Belg. 1990. PMID: 2205718 Review. French.
-
Platelet activating factor--a mediator of inflammation in the skin--medical implications.Clin Exp Dermatol. 1993 Nov;18(6):489-95. doi: 10.1111/j.1365-2230.1993.tb01015.x. Clin Exp Dermatol. 1993. PMID: 8252783 Review. No abstract available.
Cited by
-
Byssinosis: a review.Thorax. 1996 Jun;51(6):632-7. doi: 10.1136/thx.51.6.632. Thorax. 1996. PMID: 8693449 Free PMC article. Review. No abstract available.
-
Participation of collagenase and elastase in LPS-induced airway hyperresponsiveness in guinea pigs.Inflammation. 1991 Aug;15(4):317-30. doi: 10.1007/BF00917316. Inflammation. 1991. PMID: 1663085
-
LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.Immunology. 1995 Jan;84(1):36-40. Immunology. 1995. PMID: 7890304 Free PMC article.
-
Effects of CIS-19, a novel PAF receptor antagonist, on PAF-induced eosinophil recruitment and enhancement of superoxide anion generation in guinea-pigs.Naunyn Schmiedebergs Arch Pharmacol. 1995 May;351(5):529-34. doi: 10.1007/BF00171045. Naunyn Schmiedebergs Arch Pharmacol. 1995. PMID: 7643917
-
Animal models for testing anti-inflammatory drugs for treatment of bronchial hyperreactivity in asthma.Pharm Weekbl Sci. 1991 Dec 13;13(6):225-37. doi: 10.1007/BF02015576. Pharm Weekbl Sci. 1991. PMID: 1795932 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical