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Review
. 2022;20(2):324-343.
doi: 10.2174/1570159X19666210524152817.

Flavonoids, the Family of Plant-Derived Antioxidants Making Inroads into Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative Stress in Parkinson's Disease

Tapan Behl  1 , Gagandeep Kaur  1 , Aayush Sehgal  1 , Gokhan Zengin  2 , Sukhbir Singh  1 , Amirhossein Ahmadi  3 , Simona Bungau  4
Affiliations
Review

Flavonoids, the Family of Plant-Derived Antioxidants Making Inroads into Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative Stress in Parkinson's Disease

Tapan Behl et al. Curr Neuropharmacol. 2022.

Abstract

Background: Ionizing radiation from telluric sources is unceasingly an unprotected pitfall to humans. Thus, the foremost contributors to human exposure are global and medical radiations. Various evidences assembled during preceding years reveal the pertinent role of ionizing radiation- induced oxidative stress in the progression of neurodegenerative insults, such as Parkinson's disease, which have been contributing to increased proliferation and generation of reactive oxygen species.

Objective: This review delineates the role of ionizing radiation-induced oxidative stress in Parkinson's disease and proposes novel therapeutic interventions of flavonoid family, offering effective management and slowing down the progression of Parkinson's disease.

Methods: Published papers were searched in MEDLINE, PubMed, etc., published to date for indepth database collection.

Results: The oxidative damage may harm the non-targeted cells. It can also modulate the functions of the central nervous system, such as protein misfolding, mitochondria dysfunction, increased levels of oxidized lipids, and dopaminergic cell death, which accelerate the progression of Parkinson's disease at the molecular, cellular, or tissue levels. In Parkinson's disease, reactive oxygen species exacerbate the production of nitric oxides and superoxides by activated microglia, rendering death of dopaminergic neuronal cell through different mechanisms.

Conclusion: Rising interest has extensively engrossed in the clinical trial designs based on the plant-derived family of antioxidants. They are known to exert multifarious impact on neuroprotection via directly suppressing ionizing radiation-induced oxidative stress and reactive oxygen species production or indirectly increasing the dopamine levels and activating the glial cells.

Keywords: Parkinson’s disease; ROS; antioxidants; flavonoids; ionizing radiation; oxidative stress.

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Figures

Fig. (1)
Fig. (1)
Suggested pathways of cellular pathologies in Parkinson’s disease depicting different factors leading to oxidative stress.
Fig. (2)
Fig. (2)
The direct and indirect impact of ionizing radiation at the cellular level.
See this image and copyright information in PMC

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