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Review
. 2021 Jun;48(2):251-261.
doi: 10.1016/j.clp.2021.03.001.

Association of Infection in Neonates and Long-Term Neurodevelopmental Outcome

Elizabeth Sewell  1 , Jessica Roberts  2 , Sagori Mukhopadhyay  3
Affiliations
Review

Association of Infection in Neonates and Long-Term Neurodevelopmental Outcome

Elizabeth Sewell et al. Clin Perinatol. 2021 Jun.

Abstract

Perinatal and neonatal infection and associated inflammatory response may adversely affect brain development and lead to neurodevelopmental impairment. Factors that predict the risk of infection and subsequent adverse outcomes have been identified but substantial gaps remain in identifying mechanisms and interventions that can alter outcomes. This article describes the current epidemiology of neonatal sepsis, the pathogenesis of brain injury with sepsis, and the reported long-term neurodevelopment outcomes among survivors.

Keywords: Bacteremia; Bacterial meningitis; Cerebral palsy; Necrotizing enterocolitis neurodevelopment; Neonate; Preterm; Sepsis.

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Conflict of interest statement

Disclosure Dr Mukhopadhyay is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (K23HD088753).

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