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Review
. 2021 Jun;48(2):293-309.
doi: 10.1016/j.clp.2021.03.005.

Syphilis in Neonates and Infants

Alexandra K Medoro  1 , Pablo J Sánchez  2
Affiliations
Review

Syphilis in Neonates and Infants

Alexandra K Medoro et al. Clin Perinatol. 2021 Jun.

Abstract

Syphilis in neonates and infants remains a significant public health problem because it is a major cause of fetal and neonatal morbidity and mortality globally. Despite decades of experience with syphilis in adults and infants, maternal and congenital syphilis are increasing substantially in the United States. The vertical transmission, clinical manifestations, diagnosis, evaluation, treatment, and follow-up are reviewed to guide the health care professional in understanding the optimal management of this preventable disease.

Keywords: Congenital syphilis; Infant; Maternal syphilis; Reverse sequence syphilis screening; Syphilis; Syphilis screening.

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Conflict of interest statement

Disclosure Supported in part by grants (1R29 AI 34932-01 to Dr. Sánchez from the National Institute of Allergy and Infectious Diseases and by a contract (C1000 689) with the Centers for Disease Control and Prevention.

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