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Review
. 2021 Sep;99(9):2074-2090.
doi: 10.1002/jnr.24825. Epub 2021 May 24.

Dysregulation of long non-coding RNAs and their mechanisms in Huntington's disease

Xiaoping Tan  1 , Yang Liu  1 , Yan Liu  1 , Taiming Zhang  1 , Shuyan Cong  1
Affiliations
Review

Dysregulation of long non-coding RNAs and their mechanisms in Huntington's disease

Xiaoping Tan et al. J Neurosci Res. 2021 Sep.

Abstract

Extensive alterations in gene regulatory networks are a typical characteristic of Huntington's disease (HD); these include alterations in protein-coding genes and poorly understood non-coding RNAs (ncRNAs), which are associated with pathology caused by mutant huntingtin. Long non-coding RNAs (lncRNAs) are an important class of ncRNAs involved in a variety of biological functions, including transcriptional regulation and post-transcriptional modification of many targets, and likely contributed to the pathogenesis of HD. While a number of changes in lncRNAs expression have been observed in HD, little is currently known about their functions. Here, we discuss their possible mechanisms and molecular functions, with a particular focus on their roles in transcriptional regulation. These findings give us a better insight into HD pathogenesis and may provide new targets for the treatment of this neurodegenerative disease.

Keywords: mHTT; Huntington's disease; RNA; lncRNA; polyQ.

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