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Meta-Analysis
. 2022 Mar;26(1):429-441.
doi: 10.1007/s11325-021-02405-0. Epub 2021 May 25.

Association between depression and sleep quality in patients with systemic lupus erythematosus: a systematic review and meta-analysis

Rulan Yin #  1   2 , Lin Li #  3 , Lan Xu #  4 , Wenjie Sui  4 , Mei'e Niu  4 , Rong Xu  5 , Chomphoonut Srirat  6
Affiliations
Meta-Analysis

Association between depression and sleep quality in patients with systemic lupus erythematosus: a systematic review and meta-analysis

Rulan Yin et al. Sleep Breath. 2022 Mar.

Erratum in

Abstract

Background: Currently, there is no consistent understanding of the relationship between depression and sleep quality in patients with systemic lupus erythematosus (SLE). This study aimed to explore the correlation between depression and sleep quality in SLE patients.

Methods: Five English (PubMed, Web of Science, EMBASE, Cochrane Library, and CINAHL) databases were systematically searched from inception to January 12, 2021. Two authors independently screened publications and extracted data according to set inclusion and exclusion criteria. Statistical analyses were performed with STATA 16.0. Data were pooled using a random-effects model.

Results: A total of 9 identified studies matched the inclusion criteria, reporting on 514 patients with SLE in the analysis. A moderate correlation of depression with sleep quality was found (pooled r = 0.580 [0.473, 0.670]). Compared to good sleepers, patients with SLE and poor sleep quality had higher levels of depression (standardized mean difference = - 1.28 [- 1.87, - 0.69]). Depression was associated with subjective sleep quality (r = 0.332 [0.009, 0.592]), sleep latency (r = 0.412 [0.101, 0.649]), sleep disturbances (r = 0.405 [0.094, 0.645]), daytime dysfunction (r = 0.503 [0.214, 0.711]), the four dimensions of Pittsburgh Sleep Quality Index (PSQI), while no significant correlation was found in the other three PSQI dimensions.

Conclusion: Depression had a moderate correlation with sleep quality in patients with SLE. Patients with poor sleep quality tended to have higher level of depression than that of good sleepers. Awareness of the correlation may help rheumatology physicians and nurses to assess and prevent depression and improve sleep quality in patients with SLE.

Keywords: Depression; Meta-analysis; Sleep quality; Systemic lupus erythematosus.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow-chart illustrating the article search process
Fig. 2
Fig. 2
Meta-analysis of the correlation between depression and sleep quality (N = 8)
Fig. 3
Fig. 3
Meta-analysis of the correlation between depression and 7 dimensions of PSQI (N = 2)
Fig. 4
Fig. 4
Meta-analysis comparing the depression levels in patients with SLE and good sleep quality and patients with SLE and poor sleep quality (N = 4)
See this image and copyright information in PMC

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