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. 2021 May;48(5):4647-4658.
doi: 10.1007/s11033-021-06423-9. Epub 2021 May 25.

Potential role of microRNAs as biomarkers in human glioblastoma: a mini systematic review from 2015 to 2020

Manuela Rocha de Menezes  1 , Maria Eduarda Azevêdo Acioli  2 , Ana Carolina Lemos da Trindade  3 , Suéllen Pedrosa da Silva  4 , Raul Emídio de Lima  5 , Vanessa Gabryelle da Silva Teixeira  3 , Luydson Richardson Silva Vasconcelos  2
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Potential role of microRNAs as biomarkers in human glioblastoma: a mini systematic review from 2015 to 2020

Manuela Rocha de Menezes et al. Mol Biol Rep. 2021 May.

Abstract

Glioblastoma (GBM) is the most common, aggressive and malignant type of glioma, with poor prognosis, despite advances in medical knowledge and technology. It's known that some microRNAs (miRNAs) can be dysregulated and associated with tumors. We aim to investigate miRNAs that may have a role as potential biomarkers in human glioblastoma. A search was performed using PubMed, LILACS and SCIELO databases to find papers from 2015 to 2020, related to human in vitro and ex vivo data. From 99 articles, 10 were eligible and 13 dysregulated miRNAs were found with description of regulation, target(s), pathway(s) and mechanism(s). The miRNAs of interest were found and seem to be involved in development and progression of glioblastoma and used as target therapies. Understanding the mechanisms in which those miRNAs are involved and their role in epigenetic pathways that lead to cancer, as well as their potential in clinical application, may improve GBM clinical outcome (CRD42020182706, 07/10/2020, retrospectively registered).

Keywords: Biomarkers; Epigenetic; Glioblastoma; Systematic review; microRNAs.

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