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Book

Major Depressive Disorder (Nursing)

Navneet Bains, Sara Abdijadid  1 , Jennifer L. Miller  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Major Depressive Disorder (Nursing)

Navneet Bains et al.
Free Books & Documents

Excerpt

Major Depressive Disorder (MDD) is a mental health disorder characterized by at least two weeks of persistently sad mood or loss of interest in activities (anhedonia), causing significant impairment in daily life functioning, accompanied by five or more symptoms including [1]:

  1. Depressed mood most of the time

  2. Loss of interest or pleasure in activities

  3. Feelings of worthlessness or excessive guilt

  4. Lack of energy

  5. Insomnia or hypersomnia

  6. Inability to concentrate or indecisiveness

  7. Decrease or increase in appetite

  8. Psychomotor retardation or agitation

  9. Suicidal ideations

As per the Diagnostic Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria, MDD is a subclassification under depressive disorders, which also include Disruptive Mood Dysregulation Disorder, Persistent Depressive Disorder (Dysthymia), Premenstrual Dysphoric Disorder, Substance/Medication-Induced Depressive Disorder, Depressive Disorder Due to Another Medical Condition, Other Specified Depressive Disorder and Unspecified Depressive Disorder.

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Conflict of interest statement

Disclosure: Navneet Bains declares no relevant financial relationships with ineligible companies.

Disclosure: Sara Abdijadid declares no relevant financial relationships with ineligible companies.

Disclosure: Jennifer Miller declares no relevant financial relationships with ineligible companies.

References

    1. Malhi GS, Mann JJ. Depression. Lancet. 2018 Nov 24;392(10161):2299-2312. - PubMed
    1. Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, Gillespie CF, Berg T, Evces M, Newport DJ, Stowe ZN, Heim CM, Nemeroff CB, Schwartz A, Cubells JF, Ressler KJ. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry. 2008 Feb;65(2):190-200. - PMC - PubMed
    1. Green JG, McLaughlin KA, Berglund PA, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry. 2010 Feb;67(2):113-23. - PMC - PubMed
    1. Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry. 2000 Oct;157(10):1552-62. - PubMed
    1. Pedersen CB, Mors O, Bertelsen A, Waltoft BL, Agerbo E, McGrath JJ, Mortensen PB, Eaton WW. A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry. 2014 May;71(5):573-81. - PubMed

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