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Book

Substance Use Disorder (Archived)

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Substance Use Disorder (Archived)

Azmi R. Jahan et al.
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Excerpt

Substance use disorders involve excessive use of nicotine, alcohol, and other illicit substances that leads to social, academic, and occupational impairment. The most common illicit substances seen include cannabis, sedatives, hypnotics, anxiolytics, inhalants, opioids, hallucinogens, and stimulants. The specific factors of substance use disorder consist of abuse, intoxication, and physical/psychological dependence.

Different substances can be classified based on their effects on the central nervous system. These effects vary depending on the substance and can produce everything from increased energy and euphoria to profound sedation. In general, while the effects vary significantly, the initial stages of substance use disorders are characterized by positive reinforcement, where individuals experience a sense of well-being or euphoria with use. As physiological and psychological dependence progresses, an individual experiences negative reinforcement where substances primarily relieve dysphoria and unpleasant withdrawal symptoms.

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Conflict of interest statement

Disclosure: Azmi Jahan declares no relevant financial relationships with ineligible companies.

Disclosure: Doug Burgess declares no relevant financial relationships with ineligible companies.

References

    1. Kranzler HR, Li TK. What is addiction? Alcohol Res Health. 2008;31(2):93-5. - PMC - PubMed
    1. Bostwick JM. Blurred boundaries: the therapeutics and politics of medical marijuana. Mayo Clin Proc. 2012 Feb;87(2):172-86. - PMC - PubMed
    1. Merikangas KR, McClair VL. Epidemiology of substance use disorders. Hum Genet. 2012 Jun;131(6):779-89. - PMC - PubMed
    1. Grant BF, Saha TD, Ruan WJ, Goldstein RB, Chou SP, Jung J, Zhang H, Smith SM, Pickering RP, Huang B, Hasin DS. Epidemiology of DSM-5 Drug Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III. JAMA Psychiatry. 2016 Jan;73(1):39-47. - PMC - PubMed
    1. Sinha R. Chronic stress, drug use, and vulnerability to addiction. Ann N Y Acad Sci. 2008 Oct;1141:105-30. - PMC - PubMed

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