Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep 2;17(9):2873-2893.
doi: 10.1080/21645515.2021.1911204. Epub 2021 May 25.

COVID-19 vaccine platforms: Delivering on a promise?

Mark Verdecia  1 , John F Kokai-Kun  1 , Maura Kibbey  1 , Sarita Acharya  1 , Jaap Venema  1 , Fouad Atouf  1
Affiliations
Review

COVID-19 vaccine platforms: Delivering on a promise?

Mark Verdecia et al. Hum Vaccin Immunother. .

Abstract

The emergence of the novel SARS-CoV-2 and COVID-19 has brought into sharp focus the need for a vaccine to prevent this disease. Vaccines have saved millions of lives since their introduction to the public over 200 years ago. The potential for vaccination reached new heights in the mid-20th century with the development of technologies that expanded the ability to create novel vaccines. Since then, there has been continued technological advancement in vaccine development. The resulting platforms provide the promise for solutions for many infectious diseases, including those that have been with us for decades as well as those just now emerging. Each vaccine platform represents a different technology with a unique set of advantages and challenges, especially when considering manufacturing. Therefore, it is essential to understand each platform as a separate product and process with its specific quality considerations. This review outlines the relevant platforms for developing a vaccine for SARS-CoV-2 and discusses the advantages and disadvantages of each.

Keywords: COVID-19; manufacturing; platform development; vaccines.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Vaccine platforms being developed for COVID-19
Figure 2.
Figure 2.
SARS-CoV-2
See this image and copyright information in PMC

References

    1. Folkers GK, Fauci AS.. The role of US government agencies in vaccine research and development. Nat Med. 1998May;4(5 Suppl):491–94. doi:10.1038/nm0598supp-491. - DOI - PubMed
    1. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and its eradication. Geneva (CH): World Health Organization; 1988.
    1. Morales M, Tangermann RH, Wassilak SG. Progress toward polio eradication - worldwide, 2015-2016. MMWR Morb Mortal Wkly Rep. 2016May13;65(18):470–73. doi:10.15585/mmwr.mm6518a4. - DOI - PubMed
    1. Orenstein WA, Ahmed R. Simply put: vaccination saves lives. Proc Natl Acad Sci U S A. 2017Apr18;114(16):4031–33. doi:10.1073/pnas.1704507114. - DOI - PMC - PubMed
    1. Plotkin SL, Plotkin SA. A short history of vaccination. In: Plotkin SA, Orenstein WA, Offit PA, Edwards KM, editors. Plotkin’s Vaccines. 7thed. Philadelphia (PA): Elsevier; 2018. p. 1–15.

LinkOut - more resources