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Review
. 2021 May 20;24(5):365-371.
doi: 10.3779/j.issn.1009-3419.2021.101.12.

[Research Progress in Distinguishing Methods of Simultaneous Multiple Primary Lung Cancer and Intrapulmonary Metastasis]

[Article in Chinese]
Jifan Wang  1 , Te Zhang  1 , Hanlin Ding  1 , Gaochao Dong  1 , Lin Xu  1 , Feng Jiang  1
Affiliations
Review

[Research Progress in Distinguishing Methods of Simultaneous Multiple Primary Lung Cancer and Intrapulmonary Metastasis]

[Article in Chinese]
Jifan Wang et al. Zhongguo Fei Ai Za Zhi. .

Abstract
in English, Chinese

Multiple primary lung cancer (MPLC) refers to lung cancer in which two or more primary lesions occurred simultaneously or successively in different parts of the same patient's lungs. The diagnosis interval is 6 months. MPLC is divided into synchronous MPLC (sMPLC) and metachronous MPLC (mMPLC). sMPLC and intrapulmonary metastasis (IM) are different in treatment strategies and prognosis. However, there are many controversies about the distinction between the two in clinical practice. This article summarizes the current main methods of diagnosing MPLC, and focuses on the latest research progress in distinguishing MPLC from IM. It aims to provide a theoretical basis for accurate diagnosis and treatment of patients with multifocal lung cancer. .

【中文题目：同时性多原发肺癌与肺内转移鉴别方法 研究进展】 【中文摘要：多原发性肺癌（multiple primary lung cancer, MPLC）是指在同一患者肺内不同部位同时或先后发生两个或两个以上原发病灶的肺癌，以诊断时间间隔6个月为界，MPLC分为同时性MPLC（synchronous MPLC, sMPLC）和异时性MPLC（metachronous MPLC, mMPLC）。sMPLC与肺内转移（intrapulmonary metastasis, IM）在治疗策略及预后上有着极大的差异。然而，目前临床上对于二者的区分鉴别存在许多争议。本文总结了目前诊断MPLC的主要方法，并重点介绍了区分MPLC和IM的最新研究进展，旨在为多灶性肺癌患者精准的诊断和治疗提供理论依据。 】 【中文关键词：多原发性肺癌；肺内转移；肺肿瘤；精准诊断】.

Keywords: Accurate diagnosis; Intrapulmonary metastasis; Lung neoplasms; Multiple primary lung cancer.

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Figures

图 1
图 1
综合影像学评估流程图 Flowchart of radiological assessment. GGN: ground-glass nodules; GGO: ground-glass opacities; MPLC: multiple primary lung cancer; IM: intrapulmonary metastasis; SUV: standardized uptake value; ∆SUV: difference between SUVs.
图 2
图 2
分子分类算法流程图 Flowchart of molecular algorithm. AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; CHA: comprehensive histologic assessment; EGFR: epidermal growth factor receptor; KRAS: kirsten rat sarcoma viral oncogene; TP53: tumor protein 53.
图 3
图 3
综合组织评估流程图 Flowchart of comprehensive histologic assessment
See this image and copyright information in PMC

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