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Review
. 2021 May 7;47(4):171-183.
doi: 10.14745/ccdr.v47i04a01.

Practical guidance for clinical laboratories for SARS-CoV-2 serology testing

Carmen Charlton  1   2   3 , Jamil Kanji  1   2   4 , Vanessa Tran  5   6 , Julianne Kus  5   6 , Jonathan Gubbay  5   6 , Carla Osiowy  7 , Jason Robinson  8 , Inna Sekirov  9 , Michael Drebot  7 , Todd Hatchette  10 , Derek Stein  11   12 , Nadia El-Gabalawy  7 , Amanda Lang  13 , Lei Jiao  10 , Paul Levett  11 , Heidi Wood  7 , Christian Therrien  14 , L Robbin Lindsay  7 , Muhammad Morshed  9 , Jessica Forbes  6 , Antonia Dibernardo  7
Affiliations
Review

Practical guidance for clinical laboratories for SARS-CoV-2 serology testing

Carmen Charlton et al. Can Commun Dis Rep. .

Abstract

The landscape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing is rapidly evolving. While serology testing has limited diagnostic capacity for acute infection, its role in providing population-based information on positivity rates and informing evidence-based decision making for public health recommendations is increasing. With the global availability of vaccines, there is increasing pressure on clinical laboratories to provide antibody screening and result interpretation for vaccinated and non-vaccinated individuals. Here we present the most up-to-date data on SARS-CoV-2 antibody timelines, including the longevity of antibodies, and the production and detection of neutralizing antibodies. Additionally, we provide practical guidance for clinical microbiology laboratories to both verify commercial serology assays and choose appropriate testing algorithms for their local populations.

Keywords: COVID-19; SARS-CoV-2; serological testing; serology algorithms.

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Conflict of interest statement

Competing interests: None.

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