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. 2020 Nov;16(11):561-570.

Current Management of Alcohol-Associated Liver Disease

Faisal A Siddiqi  1 , Krishna C Sajja  2 , Nyan L Latt  3
Affiliations

Current Management of Alcohol-Associated Liver Disease

Faisal A Siddiqi et al. Gastroenterol Hepatol (N Y). 2020 Nov.

Abstract

Alcohol consumption is a major risk factor for various diseases worldwide and is one of the most common causes of chronic liver disease. Alcohol use has risen over the past 30 years and is forecast to continue to rise. Concurrently, there has been an increased incidence of alcohol-associated liver disease (ALD). Alcohol use, regardless of the amount, leads to years of health loss across populations when considering the strong association between alcohol consumption and overall disease burden. Given the rising incidence of ALD and associated mortality, it is imperative to study the underlying factors driving these trends. This article summarizes the diagnosis and management of ALD, with a focus on various screening and prognostic tools and treatments for alcohol-associated hepatitis.

Keywords: Alcohol-associated liver disease; alcohol-associated hepatitis; alcoholic cirrhosis; alcoholic hepatitis; cirrhosis; liver transplantation.

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Conflict of interest statement

The authors have no relevant conflicts of interest to disclose.

Figures

Figure.
Figure.
Proposed algorithm for liver transplant evaluation in patients with alcohol-associated liver disease. PEth, phosphatidylethanol; SALT, Sustained Alcohol Use Post–Liver Transplant; THC, tetrahydrocannabinol. aSALT score adapted from Lee et al.52 A score of 5 or higher has a 95% negative predictive value of predicting alcohol use posttransplant.
See this image and copyright information in PMC

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