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. 2021 Sep 13;76(10):1769-1774.
doi: 10.1093/gerona/glab147.

Benefits of Living Without Growth Hormone

Andrzej Bartke  1
Affiliations

Benefits of Living Without Growth Hormone

Andrzej Bartke. J Gerontol A Biol Sci Med Sci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Characteristics of long-lived mice with growth hormone-related mutations are favorable in terms of each of the proposed “Hallmarks of Aging.” Abbreviations: BAT = Brown Adipose Tissue; Ucp-1 = Uncoupling protein 1; VSELs = Very Small Embryonic-Like stem cells; IL-1β = Interleukin 1 beta; IL-6 = Interleukin 6; tnf-α = tumor necrosis factor alpha.
Figure 2.
Figure 2.
Individuals with a slower pace-of-life may have enhanced evolutionary fitness in their natural environment. In this example, smaller mice mature later and have fewer pups but are more likely to survive winter and reproduce in the second year of life.
See this image and copyright information in PMC

References

    1. Bartke A. Prolactin deficiency in genetically sterile dwarf mice. In: Spickett SG, ed. Endocrine Genetics. Cambridge University Press; 1967:193–197.
    1. Bartke A. Prolactin in the male: 25 years later. J Androl. 2004;25(5):661–666. doi:10.1002/j.1939-4640.2004.tb02837.x - DOI - PubMed
    1. Bartke A, Kopchick JJ. The forgotten lactogenic activity of growth hormone: important implications for rodent studies. Endocrinology. 2015;156(5):1620–1622. doi:10.1210/en.2015-1097 - DOI - PMC - PubMed
    1. Steger RW, Bartke A, Cecim M. Premature ageing in transgenic mice expressing different growth hormone genes. J Reprod Fertil Suppl. 1993;46:61–75. - PubMed
    1. Bartke A. Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology. 2003;78(4):210–216. doi:10.1159/000073704 - DOI - PubMed

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