Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep;194(5):851-854.
doi: 10.1111/bjh.17546. Epub 2021 May 25.

Acute events in children with sickle cell disease in Italy during the COVID-19 pandemic: useful lessons learned

Vania Munaretto  1 , Vincenzo Voi  2 , Giovanni Palazzi  3 , Lucia Dora Notarangelo  4 , Paola Corti  5 , Valentina Baretta  6 , Maddalena Casale  7 , Angelica Barone  8 , Daniela Cuzzubbo  9 , Piera Samperi  10 , Serena Tripodi  11 , Fiorina Giona  12 , Maurizio Miano  13 , Agostino Nocerino  14 , Gian Carlo Del Vecchio  15 , Chiara Piccolo  16 , Antonella Sau  17 , Beatrice Filippini  18 , Maria Luisa Casciana  19 , Francesco Arcioni  20 , Maddalena Migliavacca  21 , Paola Saracco  22 , Chiara Gorio  23 , Simone Cesaro  6 , Silverio Perrotta  7 , Marco Zecca  11 , Paola Giordano  15 , Silvia Fasoli  19 , Beatrice Coppadoro  1 , Giovanna Russo  10 , Laura Sainati  1 , Raffaella Colombatti  1 ; AIEOP Red Cell Disorder Working Group
Affiliations

Acute events in children with sickle cell disease in Italy during the COVID-19 pandemic: useful lessons learned

Vania Munaretto et al. Br J Haematol. 2021 Sep.
No abstract available

Keywords: COVID-19; Italy; Vaso-occlusive crisis; acute chest; children; sickle cell disease.

PubMed Disclaimer

Figures

Fig 1
Fig 1
Inpatient admission and emergency room (ER) visits for acute events in children with sickle cell disease during the first national lockdown in Italy, showing a significant reduction in the number of admissions and ER visits overall (P = 0·025 and P = 0·001 respectively), but with uneven distribution in the country, with the majority of reductions occurring in Northern Italy (P = 0·016).
Fig 2
Fig 2
Causes of inpatient admissions for children with sickle cell disease during the first national lockdown in Italy, showing significant reduction in the number of vaso‐occlusive crisis (VOCs) (A), acute chest syndrome (ACS) (B) and fever admissions (C), especially in Northern Italy, but not in admissions for other reasons (aplastic crisis, acute haemolytic anaemia, splenic sequestration) (D).
See this image and copyright information in PMC

References

    1. Megna R. First month of the epidemic caused by COVID‐19 in Italy: current status and real‐time outbreak development forecast. Glob Health Res Policy. 2020;5:43;eCollection 2020. https://ghrp.biomedcentral.com/articles/10.1186/s41256‐020‐00170‐3 - DOI - PMC - PubMed
    1. Sainati L, Biffi A. How we deal with the COVID‐19 epidemic in an Italian paediatric onco‐haematology clinic located in a region with a high density of cases. Br J Haemathol. 2020;189:640–2. - PMC - PubMed
    1. Colombatti R, Palazzi G, Masera N, Notarangelo LD, Bonetti E, Samperi P, et al. Hydroxyurea prescription, availability and use for children with sickle cell disease in Italy: results of a National Multicenter survey. Pediatr Blood Cancer. 2018;65:e26774 - PubMed
    1. Piel FB, Steinberg MH, Rees DC. Sickle cell disease. N Engl J Med. 2017;376:1561–73. - PubMed
    1. Po’ C, Colombatti R, Cirigliano A, Dalt LD, Agosto C, Benini F, et al. The management of sickle cell pain in the emergency department: a priority for health systems. Clin J Pain. 2013;29:60–3. - PubMed

Publication types