Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug;246(15):1681-1687.
doi: 10.1177/15353702211011701. Epub 2021 May 26.

The role of mediator complex subunit 19 in human diseases

Yuting Zhang  1   2 , Peifang Qin  1   2 , Linlin Tian  1   2 , Jianguo Yan  3 , Yali Zhou  1   2
Affiliations
Review

The role of mediator complex subunit 19 in human diseases

Yuting Zhang et al. Exp Biol Med (Maywood). 2021 Aug.

Abstract

Mediator is an evolutionarily conserved multi-protein complex that mediates the interaction between different proteins as a basic linker in the transcription mechanism of eukaryotes. It interacts with RNA polymerase II and participates in the process of gene expression. Mediator complex subunit 19 or regulation by oxygen 3, or lung cancer metastasis-related protein 1 is located at the head of the mediator complex; it is a multi-protein co-activator that induces the transcription of RNA polymerase II by DNA transcription factors. It is a tumor-related gene that plays an important role in transcriptional regulation, cell proliferation, and apoptosis and is closely related to the occurrence and development of the cancers of the lung, bladder, skin, etc. Here, we used the structure of mediator complex subunit 19 to review its role in tumor progression, fat metabolism, drug therapy, as well as the novel coronavirus, which has attracted much attention at present, suggesting that mediator complex subunit 19 has broad application in the occurrence and development of clinical diseases. As a tumor-related gene, the role and mechanism of mediator complex subunit 19 in the regulation of tumor growth could be of great significance for the diagnosis, prognosis, and treatment of mediator complex subunit 19 -related tumors.

Keywords: Mediator complex subunit 19; fat metabolism; novel coronavirus; tumor.

PubMed Disclaimer

Conflict of interest statement

DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Chadick JZ, Asturias FJ. Structure of eukaryotic mediator complexes. Trends Biochem Sci 2005; 30:264–71 - PubMed
    1. Singh H, Erkine AM, Kremer SB, Duttweiler HM, Davis DA, Iqbal J, Gross RR, Gross DS. A functional module of yeast mediator that governs the dynamic range of Heat-Shock gene expression. Genetics 2006; 172:2169–84 - PMC - PubMed
    1. Wen H, Feng C-C, Ding G-X, Meng D-L, Ding Q, Fang Z-J, Xia G-W, Xu G, Jiang H-W. Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2. Ann Diagnost Pathol 2013; 17:259–64 - PubMed
    1. Robinson PJ, Trnka MJ, Bushnell DA, Davis RE, Mattei PJ, Burlingame AL, Kornberg RD. Structure of a complete mediator-RNA polymerase II pre-initiation complex. Cell 2016; 166:1411–22.e16 - PMC - PubMed
    1. Lariviere L, Seizl M, Cramer P. A structural perspective on mediator function. Curr Opin Cell Biol 2012; 24:305–13 - PubMed

Publication types