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Review
. 2021 Oct;113(10):401-418.
doi: 10.1111/boc.202100009. Epub 2021 Jun 4.

The role of ligand endocytosis in notch signalling

Ekaterina Seib  1 , Thomas Klein  1
Affiliations
Review

The role of ligand endocytosis in notch signalling

Ekaterina Seib et al. Biol Cell. 2021 Oct.

Abstract

The Notch signalling receptor is a mechanoreceptor that is activated by force. This force elicits a conformational change in Notch that results in the release of its intracellular domain into the cytosol by two consecutive proteolytic cleavages. In most cases, the force is generated by pulling of the ligands on the receptor upon their endocytosis. In this review, we summarise recent work that shed a more detailed light on the role of endocytosis during ligand-dependent Notch activation and discuss the role of ubiquitylation of the ligands during this process.

Keywords: DSL ligands; Delta; Notch pathway; Serrat; endocytosis.

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References

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