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. 2021 Jul;41(7):2215-2224.
doi: 10.1161/ATVBAHA.121.316397. Epub 2021 May 27.

Homocysteine Is Associated With Future Venous Thromboembolism in 2 Prospective Cohorts of Women

Aaron W Aday  1   2 , Edward K Duran  1   3 , Martin Van Denburgh  1 , Eunjung Kim  1 , William G Christen  1 , JoAnn E Manson  1 , Paul M Ridker  4 , Aruna D Pradhan  5
Affiliations

Homocysteine Is Associated With Future Venous Thromboembolism in 2 Prospective Cohorts of Women

Aaron W Aday et al. Arterioscler Thromb Vasc Biol. 2021 Jul.

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT00000541 NCT00000479.

Keywords: biomarker; homocysteine; plasma; pulmonary embolism; venous thromboembolism.

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Figures

Figure 1.
Figure 1.. Risk of Incident VTE, PE, and DVT by Baseline BMI and Homocysteine Concentration
Participants are divided into low/high categories based on the study population median for body mass index (24.9 kg/m2) and plasma homocysteine (10.5 μmol/L). VTE indicates venous thromboembolism; PE, pulmonary embolism; DVT, deep vein thrombosis; BMI, body mass index; Hcys, homocysteine; CI, confidence interval. Adjusted for age, smoking, hormonal therapy, activity level, metabolic syndrome, post-menopausal status, glomerular filtration rate, and randomized treatment.
Figure 2.
Figure 2.. Association Between Homocysteine and Incident VTE in WHS and WAFACS
Hazard ratios and 95% confidence intervals for homocysteine in both WHS and WAFACS. WHS indicates Women’s Health Study; WAFACS, Women’s Antioxidant and Folic Acid Cardiovascular Study. Models for WHS adjusted for age, smoking, BMI, hormonal therapy, activity level, metabolic syndrome, post-menopausal status, glomerular filtration rate, and randomized treatment. Models for WAFACS adjusted for age, smoking, BMI, height, activity level, diabetes, post-menopausal status, history of hypertension, randomized treatment, and baseline venous thromboembolism.
See this image and copyright information in PMC

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