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Controlled Clinical Trial
. 2021 May 26;21(1):221.
doi: 10.1186/s12905-021-01356-8.

Comparison of cervical cancer screening by self-sampling papillomavirus test versus pap-smear in underprivileged women in France

Laura Reques  1 , Camille Rolland  2 , Anne Lallemand  2 , Najat Lahmidi  2 , Ezequiel Aranda-Fernández  2 , Antonio Lazzarino  3 , Julie Bottero  4 , Françoise Hamers  5 , Christine Bergeron  6 , Ken Haguenoer  7   8 , Guy Launoy  9 , Niklas Luhmann  2
Affiliations
Controlled Clinical Trial

Comparison of cervical cancer screening by self-sampling papillomavirus test versus pap-smear in underprivileged women in France

Laura Reques et al. BMC Womens Health. .

Abstract

Background: The purpose of this study was to compare cervical cancer screening by pap smear (PS) versus preliminary HPV testing based on self-collected samples (SC-HPV).

Methods: Interventional study among underprivileged women from 25 to 65 years old in four French cities. The control group (CG) was referred for a PS. The experimental group (EG) conducted a SC-HPV test followed by a PS in case of positivity. Differences on screening completion and cytological abnormalities were analysed by logistic and Cox regression.

Results: 383 women were assigned to the EG and 304 to the CG. The screening completion proportion was 39.5% in the CG compared to 71.3% in the EG (HR = 2.48 (CI 95% [1.99-3.08]; p < 0.001). The proportion of cytological abnormalities was 2.0% in the CG and 2.3% in the EG (OR = 1.20 (CI 95% [0.42-3.40]; p = 0.7). The proportion of participants lost to follow-up was 60.5% in the CG and 63.2% in the EG HPV positive (p = 0.18).

Conclusion: Providing an SC-HPV-test increased the participation of underprivileged women in CCS. Nevertheless, the significant number of lost to follow-up in both groups can undermine the initial benefits of the strategy for HPV positive women. Registration: Clinicaltrials.gov: NCT03118258.

Keywords: Cervical cancer; Papillomavirus; SC-HPV; Screening; Vulnerability.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Fig. 1
Fig. 1
Study flowchart
Fig. 2
Fig. 2
Sub-group analysis using a forest plot representing the cervical cancer screening completion rate
Fig. 3
Fig. 3
Sub-group analysis using a forest plot representing the detection of cytological cervical abnormalities
See this image and copyright information in PMC

References

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