Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May 26;14(1):72.
doi: 10.1186/s13048-021-00816-x.

Management of advanced ovarian cancer in Spain: an expert Delphi consensus

Andres Redondo  1 , Ana Oaknin  2 , Maria Jesus Rubio  3 , Maria-Pilar Barretina-Ginesta  4 , Ana de Juan  5 , Luis Manso  6 , Ignacio Romero  7 , Cristina Martin-Lorente  8 , Andres Poveda  9 , Antonio Gonzalez-Martin  10
Affiliations

Management of advanced ovarian cancer in Spain: an expert Delphi consensus

Andres Redondo et al. J Ovarian Res. .

Abstract

Background: To determine the state of current practice and to reach a consensus on recommendations for the management of advanced ovarian cancer using a Delphi survey with a group of Spanish gynecologists and medical oncologists specially dedicated to gynecological tumors.

Methods: The questionnaire was developed by the byline authors. All questions but one were answered using a 9-item Likert-like scale with three types of answers: frequency, relevance and agreement. We performed two rounds between December 2018 and July 2019. A consensus was considered reached when at least 75% of the answers were located within three consecutive points of the Likert scale.

Results: In the first round, 32 oncologists and gynecologists were invited to participate, and 31 (96.9%) completed the online questionnaire. In the second round, 27 (87.1%) completed the online questionnaire. The results for the questions on first-line management of advanced disease, treatment of patients with recurrent disease for whom platinum might be the best option, and treatment of patients with recurrent disease for whom platinum might not be the best option are presented.

Conclusions: This survey shows a snapshot of current recommendations by this selected group of physicians. Although the majority of the agreements and recommendations are aligned with the recently published ESMO-ESGO consensus, there are some discrepancies that can be explained by differences in the interpretation of certain clinical trials, reimbursement or accessibility issues.

Keywords: Advanced disease; Consensus; Management; Ovarian cancer; Recurrent disease.

PubMed Disclaimer

Conflict of interest statement

A. Redondo reports honoraria and advisory/consultancy (MSD, AstraZeneca, Roche, GSK, Clovis, PharmaMar, Lilly, Amgen), research grant/funding to his institution (Eisai, PharmaMar, Roche), travel/accommodation/expenses (AstraZeneca, Tesaro, PharmaMar, Roche), and speakers bureau (MSD, AstraZeneca, Roche, GSK, Clovis, PharmaMar), outside the submitted work.

A. Oaknin has served on advisory boards for Roche, AstraZeneca, PharmaMar, Clovis Oncology, Tesaro, Inmunogen and Genmab and received support for travel or accommodation from Roche, AstraZeneca, and PharmaMar; she also reports payments to the institution from Abbvie Deutschland, Abililty Pharmaceuticals, Advaxis Inc., Aeterna Zentaris, AMGEM, SA, Aprea Therapeutics AB, Clovis Oncology Inc., EISAI limited LTD, F. Hoffmann – La Roche LTD, Regeneron Pharmaceuticals, Immunogen Inc., Merck, Sharp & Dohme de España SA, Millennium Pharmaceuticals Inc., Pharma Mar SA, Tesaro Inc., BMS, Bristrol Meyers Squibb.

M.J. Rubio has served on advisory boards for MSD, AstraZeneca, Roche, GSK, Clovis, PharmaMar and received support for travel or accommodation from Roche, AstraZeneca, and PharmaMar.

M-P. Barretina-Ginesta has served on Advisory boards for Roche, AstraZeneca, PharmaMar, Clovis Oncology, GSK, Merck Sharp & Dohme; has received speaker bureau honoraria from AstraZeneca, Roche, PharmaMar, GSK, Clovis Oncology and received support for travel or accommodation from Roche, AstraZeneca, GSK and PharmaMar.

A. de Juan reports personal fees and other from Roche, AstraZeneca, Pharma Mar, Clovis Oncology, Tesaro, Eisai Ltd., Pierre-Fabre and Pfizer, outside the submitted work.

L. Manso has received advisory/consultancy honorarium from AstraZeneca, Clovis Oncology, Genmab, GSK, Merck Sharp & Dohme, Novartis, Pfizer/Merck, PharmaMar, Roche; has received speaker bureau/expert testimony honorarium from AstraZeneca, PharmaMar, Roche, GSK, Roche; has received research grant/funding from TESARO: A GSK Company; and has received travel/accommodation/expenses from AstraZeneca, Novartis, Roche, TESARO: A GSK Company.

I. Romero has received speaker’s bureau honorarium from AstraZeneca, Pharmamar, GSK, Clovis, Roche; has received advisory board honorarium from AstraZeneca, GSK, Clovis, Roche; has received travel/expenses from AstraZeneca, Pharmamar, GSK, Roche; and has received research grant/funding from Roche, GSK.

C. Martin-Lorente reports honoraria and advisory/consultancy (AstraZeneca, Clovis Oncology, GSK, MSD, PharmaMar, Roche); travel/accommodation/expenses (AstraZeneca, Clovis Oncology, GSK, MSD, PharmaMar, Roche); and speakers bureau (AstraZeneca, Clovis Oncology, GSK, MSD, PharmaMar, Roche).

A. Poveda has had a consulting or advisory role for AstraZeneca, PharmaMar, Roche, Clovis Oncology, and Tesaro; and has received travel/accommodations/expenses from PharmaMar.

A. Gonzalez-Martín has received advisory/consultancy honorarium from Amgen, AstraZeneca, Clovis Oncology, Genmab, GSK, ImmunoGen, Merck Sharp & Dohme, Novartis, Oncoinvent, Pfizer/Merck, PharmaMar, Roche, Sotio; has received speaker bureau/expert testimony honorarium from AstraZeneca, PharmaMar, Roche, GSK; has received research grant/funding from Roche, TESARO: A GSK Company; and has received travel/accommodation/expenses from AstraZeneca, Pharmamar, Roche, TESARO: A GSK Company.

Figures

Fig. 1
Fig. 1
Preference of primary debulking surgery over neoadjuvant chemotherapy in different stage IV scenarios
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Wright JD, Chen L, Tergas AI, Patankar S, Burke WM, Hou JY, Neugut AI, Ananth CV, Hershman DL. Trends in relative survival for ovarian cancer from 1975 to 2011. Obstet Gynecol. 2015;125(6):1345–1352. doi: 10.1097/AOG.0000000000000854. - DOI - PMC - PubMed
    1. Colombo N, Sessa C, du Bois A, Ledermann J, McCluggage WG, McNeish I, et al. ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent diseasedagger. Ann Oncol. 2019;30(5):672–705. doi: 10.1093/annonc/mdz062. - DOI - PubMed
    1. Francis J, Coakley N, Elit L, Mackay H. The gynecologic Cancer disease site group. Systemic therapy for recurrent epithelial ovarian cancer: a clinical practice guideline. Curr Oncol. 2017;24(6):e540–e546. doi: 10.3747/co.24.3824. - DOI - PMC - PubMed
    1. Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Berek JS, Chen LM, Cristea M, DeRosa M, ElNaggar AC, Gershenson DM, Gray HJ, Hakam A, Jain A, Johnston C, Leath III CA, Liu J, Mahdi H, Matei D, McHale M, McLean K, O’Malley DM, Penson RT, Percac-Lima S, Ratner E, Remmenga SW, Sabbatini P, Werner TL, Zsiros E, Burns JL, Engh AM. NCCN guidelines insights: ovarian cancer, version 1.2019. J Natl Compr Cancer Netw. 2019;17(8):896–909. doi: 10.6004/jnccn.2019.0039. - DOI - PubMed