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Case Reports
. 2021 May 26;8(4):e1021.
doi: 10.1212/NXI.0000000000001021. Print 2021 Jul.

Single-Dose Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

Martijn Beudel  1 , Fleur Rövekamp  2 , Diederik van de Beek  2 , Matthijs Brouwer  2
Affiliations
Case Reports

Single-Dose Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

Martijn Beudel et al. Neurol Neuroimmunol Neuroinflamm. .
No abstract available

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Figures

Figure
Figure. Axial MRI FLAIR and Contrast-Enhanced T1 Images (Radiologic Convention, Left = Right) of the 2 Patients at Baseline (T = 0) and after 6 months (T+6 M)
In patient 1 (upper row), at baseline, multiple hyperintense lesions on the fluid-attenuated inverse recovery (FLAIR) sequence were visible. The largest was located in the left parietal cortex. The lesions included the U fibers. After IV gadolinium, no contrast enhancement was visible. At ±6 months, the size of the lesions had decreased and atrophy was visible in the affected areas. In patient 2 (lower row), at baseline, multiple hyperintense lesions on the FLAIR sequence were visible. The largest was located in the left parietal cortex. The lesions included the U fibers. After IV gadolinium, ring enhancement was visible. At ±6 months, the lesions were less outspoken and no contrast enhancement was visible anymore.
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