Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May 10:12:666725.
doi: 10.3389/fphar.2021.666725. eCollection 2021.

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Rafael Fernades Costa  1 , Larissa Córdova Turones  2 , Keilah Valéria Naves Cavalcante  3 , Ismael Aureliano Rosa Júnior  1   4 , Carlos Henrique Xavier  5 , Lucimar Pinheiro Rosseto  1 , Hamilton Barbosa Napolitano  1   6 , Patrícia Ferreira da Silva Castro  1   7 , Marcos Luiz Ferreira Neto  8 , Gustavo Mota Galvão  9 , Ricardo Menegatti  9 , Gustavo Rodrigues Pedrino  3 , Elson Alves Costa  2 , José Luis Rodrigues Martins  1 , James Oluwagbamigbe Fajemiroye  2
Affiliations
Review

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Rafael Fernades Costa et al. Front Pharmacol. .

Abstract

Low quality of life and life-threatening conditions often demand pharmacological screening of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole analogs. The substitution, replacement, or removal of functional groups on a pyrazole ring appears consistent with diverse molecular interactions, efficacy, and potency of these analogs. This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyrazole analogs to advance structure-related pharmacological profiles and rational design of new analogs. Numerous interactions of these derivatives at their targets could impact future research considerations and prospects while offering opportunities for optimizing therapeutic activity with fewer adverse effects.

Keywords: activities; derivatives; functional groups; heterocyclic ring; interactions.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Effects evoked by pyrazole analogs in different cells target.
FIGURE 2
FIGURE 2
Functional groups that confer some distinctive interactions and activities on pyrazole analogs.
See this image and copyright information in PMC

References

    1. Abdelazeem A. H., El-Din A. G. S., El-Saadi M. T., El-Moghazy S. M., Amin N. H. (2020). Design, Synthesis and Biological Evaluation of Diarylpyrazole/triazole Bearing 1,3,4- Oxadiazole Moiety as Coxs Inhibitors Endowed with Potential Anti-inflammatory and Analgesic Activities. Rese. Jour. Pharm. Technol. 13 (9), 4255–4262. 10.5958/0974-360X.2020.00751.9 - DOI
    1. Abdellatif K. R. A., Fadaly W. A. A., Mostafa Y. A., Zaher D. M., Omar H. A. (2019). Thiohydantoin Derivatives Incorporating a Pyrazole Core: Design, Synthesis and Biological Evaluation as Dual Inhibitors of Topoisomerase-I and Cycloxygenase-2 with Anti-cancer and Anti-inflammatory Activities. Bioorg. Chem. 91, 103132. 10.1016/j.bioorg.2019.103132 - DOI - PubMed
    1. Abdellatif K. R. A., Abdelall E. K. A., Lamie P. F., Labib M. B., El-Nahaas E.-S., Abdelhakeem M. M. (2020). New Pyrazole Derivatives Possessing Amino/methanesulphonyl Pharmacophore with Good Gastric Safety Profile: Design, Synthesis, Cyclooxygenase Inhibition, Anti-inflammatory Activity and Histopathological Studies. Bioorg. Chem. 95, 103540. 10.1016/j.bioorg.2019.103540 - DOI - PubMed
    1. Al-Omar M. A. (2010). Synthesis and Antimicrobial Activity of New 5-(2-Thienyl)-1,2,4-Triazoles and 5-(2-Thienyl)-1,3,4-Oxadiazoles and Related Derivatives. Molecules 15, 502–514. 10.3390/molecules15010502 - DOI - PMC - PubMed
    1. Azimi F., Azizian H., Najafi M., khodarahmi G., hassanzadeh M., Saghaei L., et al. (2021). Design and Synthesis of Novel Pyrazole-Benzofuran Hybrids: In Vitro α-glucosidase Inhibitory Activity, Kinetic and Molecular Modeling Study. Res. Square. 10.21203/rs.3.rs-288227/v1 - DOI - PMC - PubMed

LinkOut - more resources