Review

. 2021 May 10:12:666725.

doi: 10.3389/fphar.2021.666725. eCollection 2021.

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Rafael Fernades Costa¹, Larissa Córdova Turones², Keilah Valéria Naves Cavalcante³, Ismael Aureliano Rosa Júnior^{1

4}, Carlos Henrique Xavier⁵, Lucimar Pinheiro Rosseto¹, Hamilton Barbosa Napolitano^{1

6}, Patrícia Ferreira da Silva Castro^{1

7}, Marcos Luiz Ferreira Neto⁸, Gustavo Mota Galvão⁹, Ricardo Menegatti⁹, Gustavo Rodrigues Pedrino³, Elson Alves Costa², José Luis Rodrigues Martins¹, James Oluwagbamigbe Fajemiroye²

Affiliations

¹ Universitary Center of Anápolis, UniEvangélica, Anápolis, Brazil.
² Laboratory of Pharmacology of Natural and Synthetic Products, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
³ Center for Neuroscience and Cardiovascular Research, Department of Physiology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
⁴ Institute of Science, Technology and Quality (ICTQ), Anápolis, Brazil.
⁵ Systems Neurobiology Laboratory, Department of Physiology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
⁶ Theoretical and Structural Chemistry Group, Universidade Estadual de Goiás, Anápolis, Brazil.
⁷ Goiás State University, Itumbiara, Brazil.
⁸ Laboratory of Electrophysiology and Cardiovascular Physiology, Departament of Physiology, Institute of Biomedical Science, Federal University of Uberlândia, Uberlândia, Brazil.
⁹ Laboratory of Medicinal Pharmaceutical Chemistry, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil.

PMID: 34040529
PMCID: PMC8141747
DOI: 10.3389/fphar.2021.666725

Review

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Rafael Fernades Costa et al. Front Pharmacol. 2021.

. 2021 May 10:12:666725.

doi: 10.3389/fphar.2021.666725. eCollection 2021.

Authors

Affiliations

¹ Universitary Center of Anápolis, UniEvangélica, Anápolis, Brazil.
² Laboratory of Pharmacology of Natural and Synthetic Products, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
³ Center for Neuroscience and Cardiovascular Research, Department of Physiology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
⁴ Institute of Science, Technology and Quality (ICTQ), Anápolis, Brazil.
⁵ Systems Neurobiology Laboratory, Department of Physiology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
⁶ Theoretical and Structural Chemistry Group, Universidade Estadual de Goiás, Anápolis, Brazil.
⁷ Goiás State University, Itumbiara, Brazil.
⁸ Laboratory of Electrophysiology and Cardiovascular Physiology, Departament of Physiology, Institute of Biomedical Science, Federal University of Uberlândia, Uberlândia, Brazil.
⁹ Laboratory of Medicinal Pharmaceutical Chemistry, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil.

PMID: 34040529
PMCID: PMC8141747
DOI: 10.3389/fphar.2021.666725

Abstract

Low quality of life and life-threatening conditions often demand pharmacological screening of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole analogs. The substitution, replacement, or removal of functional groups on a pyrazole ring appears consistent with diverse molecular interactions, efficacy, and potency of these analogs. This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyrazole analogs to advance structure-related pharmacological profiles and rational design of new analogs. Numerous interactions of these derivatives at their targets could impact future research considerations and prospects while offering opportunities for optimizing therapeutic activity with fewer adverse effects.

Keywords: activities; derivatives; functional groups; heterocyclic ring; interactions.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**FIGURE 1**
Effects evoked by pyrazole analogs in different cells target.

**FIGURE 2**
Functional groups that confer some distinctive interactions and activities on pyrazole analogs.

See this image and copyright information in PMC

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Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

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Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Authors

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Abstract

Conflict of interest statement

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