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Review
. 2021 May 15;13(5):400-408.
doi: 10.4251/wjgo.v13.i5.400.

Update on the management of the gastrointestinal effects of radiation

Hannah McCaughan  1 , Stephen Boyle  1 , John J McGoran  2
Affiliations
Review

Update on the management of the gastrointestinal effects of radiation

Hannah McCaughan et al. World J Gastrointest Oncol. .

Abstract

Radiation therapy is a long-established and essential modality in the treatment of many cancers. It is well known that tissue within a field of radiation can suffer indiscriminate effects, leading to acute and chronic problems. The gastrointestinal tract may be adversely affected by radiation. From the mouth to the rectum, patients can experience troublesome symptoms that require the concerted input of specialist teams. Interventions range from nursing care, dietetic optimization, pharmacological management, and mechanical procedures through endoscopy and surgery. Quality evidence exists mainly for radiation induced effects in four distinct areas of the gastrointestinal tract: oral mucosa, esophagus, small bowel, and rectum. This review explores the experiences of oncology and gastrointestinal teams in managing the most common conditions and some of the different practices for radiation associated morbidity.

Keywords: Endoscopy; Radiation; Stricture.

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Conflict of interest statement

Conflict-of-interest statement: There are no conflicts of interest.

References

    1. Jaffray DA, Gospodarowicz MK. Radiation Therapy for Cancer. In: Gelband H, Jha P, Sankaranarayanan R, Horton S, editors. Cancer: Disease Control Priorities, Third Edition (Volume 3). Washington (DC): The International Bank for Reconstruction and Development/The World Bank; 2015 Nov 1. Chapter 14. - PubMed
    1. UK Cancer Research. Worldwide Cancer statistics [Internet]. [cited 28 March, 2020] Available from: https://www.cancerresearchuk.org/health-professional/cancer-statistics/w... .
    1. Andreyev J. Gastrointestinal complications of pelvic radiotherapy: are they of any importance? Gut. 2005;54:1051–1054. - PMC - PubMed
    1. Andreyev HJ, Davidson SE, Gillespie C, Allum WH, Swarbrick E British Society of Gastroenterology; Association of Colo-Proctology of Great Britain and Ireland; Association of Upper Gastrointestinal Surgeons; Faculty of Clinical Oncology Section of the Royal College of Radiologists. Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer. Gut. 2012;61:179–192. - PMC - PubMed
    1. Loge L, Florescu C, Alves A, Menahem B. Radiation enteritis: Diagnostic and therapeutic issues. J Visc Surg. 2020;157:475–485. - PubMed

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