Renal Cell Carcinoma Metastasis to the Breast: A Rare Presentation

Abstract

Worldwide breast malignancy is the most common cancer in women; however, metastases to the breast from extramammary malignancies are very rare and only a few sporadic cases are reported in the international literature. In this article, the authors report a case of a 73-year-old woman, who underwent nephrectomy for clear cell renal cell carcinoma and 3 years later presented with a breast metastasis from renal cell carcinoma (clear cell type).

Figure 1

Ultrasound showing malignant looking left renal mass with mixed solid and cystic component.

Figure 2

Ultrasound showing hypoechoic masses within the pancreas.

Figure 3

CT showing confirmed a large malignant looking left renal mass with central necrosis.

Figure 4

Follow-up CT of the abdomen showing liver deposits.

Figure 5

CT of the brain with contrast showing brain metastasis with surrounding edema.

Figure 6

(a) Bilateral mammogram MLO view showing rounded density in the upper part of the right breast. (b) Mammogram in CC view showing a rounded right breast dense lesion.

Figure 7

New lesion as compared to previous mammogram.

Figure 8

US showing a hypoechoic solid mass lesion in the right breast at 1 o'clock.

Figure 9

The standard H&E-stained section showing cells with small nuclei and abundant clear cytoplasm typical of clear cell RCC.

Figure 10

Image shows positive immunohistochemical cell nucleus staining with PAX8.

Figure 11

Image shows positive cell membrane staining with carbonic anhydrase.