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. 2021 Apr 19;16(1):22.
doi: 10.5334/gh.950.

The World Heart Federation Global Study on COVID-19 and Cardiovascular Disease

Karen Sliwa  1   2 , Kavita Singh  3 , Lana Raspail  4 , Dike Ojji  5 , Carolyn S P Lam  6   7 , Friedrich Thienemann  8   9 , Junbo Ge  10 , Amitava Banerjee  11 , L Kristin Newby  12 , Antonio Luiz P Ribeiro  13 , Samuel Gidding  4 , Fausto Pinto  14 , Pablo Perel  15 , Dorairaj Prabhakaran  16
Affiliations

The World Heart Federation Global Study on COVID-19 and Cardiovascular Disease

Karen Sliwa et al. Glob Heart. .

Abstract

Background: The emergence of novel coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), has presented an unprecedented global challenge for the healthcare community. The ability of SARS-CoV-2 to get transmitted during the asymptomatic phase, and its high infectivity have led to the rapid transmission of COVID-19 beyond geographic regions facilitated by international travel, leading to a pandemic. To guide effective control and interventions, primary data is required urgently, globally, including from low- and middle-income countries where documentation of cardiovascular manifestations and risk factors in people hospitalized with COVID-19 is limited.

Objectives: This study aims to describe the cardiovascular manifestations and cardiovascular risk factors in patients hospitalized with COVID-19.

Methods: We propose to conduct an observational cohort study involving 5000 patients recruited from hospitals in low-, middle- and high-income countries. Eligible adult COVID-19 patients will be recruited from the participating hospitals and followed-up until 30 days post admission. The outcomes will be reported at discharge and includes the need of ICU admission, need of ventilator, death (with cause), major adverse cardiovascular events, neurological outcomes, acute renal failure, and pulmonary outcomes.

Conclusion: Given the enormous burden posed by COVID-19 and the associated severe prognostic implication of CVD involvement, this study will provide useful insights on the risk factors for severe disease, clinical presentation, and outcomes of various cardiovascular manifestations in COVID-19 patients particularly from low and middle income countries from where the data remain scant.

Keywords: COVID-19; HIV; cardiovascular disease; chagas disease; cohort; coronavirus; registry; rheumatic heart disease; survey.

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Conflict of interest statement

The authors have no competing interests to declare.

Figures

Figure 1
Figure 1
Global Map of COVID-19 pandemic by region; adapted from World Heart Federation Briefing on Prevention: Coronavirus Disease 2019 (COVID-19) in Low-Income Countries [4] and Management of Cardiovascular Disease Patients With Confirmed or Suspected COVID-19 in Limited Resource Settings [5].
Figure 2
Figure 2
COVID-19 research output (in percentage) – Bibliometric analysis of the WHO COVID-19 research database.
See this image and copyright information in PMC

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