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. 2021 May 4;16(1):35.
doi: 10.5334/gh.920.

Global Burden of Aortic Aneurysm and Attributable Risk Factors from 1990 to 2017

Linyan Wei  1   2   3 , Xiang Bu  4   2   3 , Xiqiang Wang  1   2   3 , Jing Liu  1   2   3 , Aiqun Ma  1   2   3 , Tingzhong Wang  1   2   3
Affiliations

Global Burden of Aortic Aneurysm and Attributable Risk Factors from 1990 to 2017

Linyan Wei et al. Glob Heart. .

Abstract

Background: To date, our understanding of the global aortic aneurysm (AA) burden distribution is very limited.

Objective: To assess a full view of global AA burden distribution and attributable risk factors from 1990 to 2017.

Methods: We extracted data of AA deaths, disability-adjusted life years (DALYs), and their corresponding age-standardized rates (ASRs), in general and by age/sex from the 2017 Global Burden of Disease (GBD) study. The current AA burden distribution in 2017 and its changing trend from 1990 to 2017 were separately showed. The spatial divergence was discussed from four levels: global, five social-demographic index regions, 21 GBD regions, and 195 countries and territories. We also estimated the risk factors attributable to AA related deaths.

Results: Globally, the AA deaths were 167,249 with an age-standardized death rate (ASDR) of 2.19/100,000 persons in 2017, among which the elderly and the males accounted for the majority. Although reductions in ASRs were observed in developed areas, AA remained an important health issue in those relatively underdeveloped areas and might be much more important in the near future. AA may increasingly affect the elderly and the female population. Similar patterns of AA DALYs burden were noted during the study period. AA burden attributable to high blood pressure and smoking decreased globally and there were many heterogeneities in their distribution.

Discussion: AA maintained an incremental public health issue worldwide. The change pattern of AA burden was heterogeneous across locations, ages, and sexes and it is paramount to improve resource allocation for more effective and targeted prevention strategies. Also, prevention of tobacco consumption and blood pressure control should be emphasized.

Keywords: aortic aneurysm; deaths; disability-adjusted life years; global burden of disease; risk factors.

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Conflict of interest statement

The authors have no competing interests to declare.

Figures

Figure 1
Figure 1
The global deaths burden of AA in 195 countries and territories. A. The absolute number of AA death cases in 2017. B. The ASDR (per 100,000 persons) of AA in 2017. C. The EAPC of AA ASDRs between 1990 and 2017. AA, aortic aneurysm; ASDR, age standardized death rate; EAPC, estimated annual percentage change.
Figure 2
Figure 2
The change trends of ASDR/age-standardized DALY rate (per 100,000 persons) globally and among different SDI quintiles between 1990 and 2017. A. ASDR. B. Age standardized DALY rate. ASDR, age-standardized death rate; DALY, disability-adjusted life year.
Figure 3
Figure 3
The proportion of the three age groups (15–49 years, 50–69 years and 70+ years) for aortic aneurysm deaths globally and in five SDI quintiles between 1990 and 2017. SDI: social-demographic index.
Figure 4
Figure 4
The correlation between the EAPC of deaths/DALYs and (A, B) the corresponding ASRs in 1990 and (C, D) HDI in 2017. The size of circle is increased with the number of death cases of aortic aneurysm. ASR, age-standardized death rate; DALYs, disability-adjusted life years; EAPC, estimated annual percentage change; HDI, human development index.
Figure 5
Figure 5
The proportion of deaths attributable to high systolic blood pressure and smoking globally and in five SDI quintiles between 1990 and 2017. SDI: social-demographic index.
Figure 6
Figure 6
The proportion of deaths attributable to high systolic blood pressure/smoking (A) globally and in 21 GBD regions and (B) in different age groups in 1990 and 2017.
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