Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar;10(3):1479-1484.
doi: 10.4103/jfmpc.jfmpc_2015_20. Epub 2021 Apr 8.

Seroprevalence of anti-SARS-CoV-2 antibodies in Indore, Madhya Pradesh: A community-based cross-sectional study, August 2020

Salil Sakalle  1 , Satish Saroshe  1 , Harish Shukla  1 , Anita Mutha  1 , Ameya Vaze  2 , Arpit Arora  3 , Aditya Athotra  4 , Sudarshan Ramaswamy  4 , Arania Jain  5 , Meera Dhuria  4 , Anil D Patil  4 , Arvind Rai  4 , Suneela Garg  6 , Sudhir K Jain  4 , Jyoti Bindal  1 , Sujeet K Singh  4
Affiliations

Seroprevalence of anti-SARS-CoV-2 antibodies in Indore, Madhya Pradesh: A community-based cross-sectional study, August 2020

Salil Sakalle et al. J Family Med Prim Care. 2021 Mar.

Abstract

Background: In India, laboratory diagnosis of SARS - CoV-2 infection has been mostly based on real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Studies have shown that Viral titres peak within the first week of symptoms but may decline later hampering RT-PCR-based diagnostic strategies. Exact estimate is difficult under high-risk screening strategy with evidences of having large number of asymptomatic cases. This has prompted a call for adoption of antibody testing as potential source of data.

Materials and methods: A cross-sectional study with a sample size of 7000 was conducted for 15 days including all the 85 wards under Indore Municipal Corporation. Stratified Random Sampling was used to collect the samples. Trained teams collected basic sociodemographic information and serum samples which were tested for the presence of specific antibodies to COVID-19 using ICMR-Kavach IgG ELISA kits. The data collected was compiled and analysed using appropriate statistical software.

Results: Overall weighted seroprevalence of the study population was found to be 7.75%. The prevalence in males and females was comparable (7.91% vs 7.57%). Highest seropositivity (10.04%) was seen among individuals aged more than 60 years. Total number of infections in the population were estimated to be 2,03,160. Overall Case Infection Ratio was found to be 27.43.

Conclusion: The current seroprevalence study provides information on proportion of the population exposed, but the correlation between presence and absence of antibodies is not a marker of total or partial immunity. It must also be noted that more than 90 percent of the population is still susceptible for COVID-19 infection. Hence, non-pharmaceutical interventions like respiratory hygiene, physical distancing, hand sanitization, usage of personal protective equipment such as masks and implementation of public health measures need to be continued.

Keywords: Community based; Indore; SARS-CoV-2; infection; seroprevalence.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Heat map of Indore city COVID-19 Case prevalence (left) and SARS-CoV-2 antibodies Seroprevalence (right) as on 31st July 2020
See this image and copyright information in PMC

References

    1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–33. - PMC - PubMed
    1. World Health Organization. WHO announces COVID-19 outbreak a pandemic [Internet] World Health Organisation. World Health Organization; 2020. p. 1. cited 2020 Jul 23. Available from: https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus... .
    1. Worldometer. Coronavirus Cases [Internet]. Worldometer. 2020. pp. 1–22. cited 2020 Jul 23. Available from: https://www.worldometers.info/coronavirus/
    1. Ministry of Health and Family Welfare. Update on Novel Coronavirus: One positive case reported in Kerala [Internet]. Press Information Bureau. 2020. p. 1. cited 2020 Jul 23. Available from: https://pib.gov.in/PressReleseDetail.aspx?PRID=1601095 .
    1. The Lancet. India under COVID-19 Lockdown. Lancet. 2020;395:1315. https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(20)30938-7.pdf . - PMC - PubMed

LinkOut - more resources