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Case Reports
. 2021 Apr 24:12:81-84.
doi: 10.1016/j.jdcr.2021.04.006. eCollection 2021 Jun.

Clinical features of tumor necrosis factor-α-inhibitor induced chilblain lupus: A case series

Nadine Shabeeb  1 , Molly Hinshaw  1 , Susan Pei  2 , Lauren Craddock  3 , Thomas Keenan  1 , Justin Endo  1
Affiliations
Case Reports

Clinical features of tumor necrosis factor-α-inhibitor induced chilblain lupus: A case series

Nadine Shabeeb et al. JAAD Case Rep. .
No abstract available

Keywords: ANA, antinuclear antibody; ATIL, anti-TNF-α-induced lupus; CCLE, chronic cutaneous lupus erythematosus; DILE, drug-induced lupus erythematosus; SCLE, subacute cutaneous lupus erythematosus; SLE, systemic lupus erythematous; TNF inhibitor; TNF, tumor necrosis factor; anti-TNF-α-induced lupus; chilblain lupus; drug-induced lupus erythematosus; pernio; tumor necrosis factor α.

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Conflict of interest statement

None declared.

Figures

Fig 1
Fig 1
Chilblain lupus associated with TNF-α inhibitor therapy: Clinical images from cases 1 (1A, 1B) and 2 (1C) A and B, Light pink papules on the dorsal and lateral aspects of multiple fingers. C, Violaceous papules on the dorsal and lateral edges of the right first and second fingers.
Fig 2
Fig 2
Chilblain lupus associated with TNF-α inhibitor therapy: Punch biopsy specimen from Case 1 (A, B, C). Hematoxylin-eosin stains; original magnification: ×4 (A) and ×10 (B and C), demonstrating a superficial and deep perivascular and periadnexal lymphocytic infiltrate on acral skin, consistent with chilblain lupus.
Fig 3
Fig 3
Chilblain lupus associated with TNF-α inhibitor therapy: Punch biopsy specimens from cases 2 (A) and 3 (B, C). A, Alcian-blue stain, original magnification: ×10, highlighting mucin in the interstitial dermis. Hematoxylin-eosin stains, original magnification: B, ×4 and C, ×10 demonstrating a dermal perivascular and periadnexal lymphocytic infiltrate, with focal interface changes and rare necrotic keratinocytes.
See this image and copyright information in PMC

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