Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;38(1):e3478.
doi: 10.1002/dmrr.3478. Epub 2021 Jun 5.

Association of sarcopenia with a higher risk of infection in patients with type 2 diabetes

Yongze Zhang  1   2   3   4 , Suiyan Weng  1   3   4 , Lingning Huang  1   2   3   4 , Ximei Shen  1   2   3   4 , Fengying Zhao  1   2   3   4 , Sunjie Yan  1   2   3   4
Affiliations

Association of sarcopenia with a higher risk of infection in patients with type 2 diabetes

Yongze Zhang et al. Diabetes Metab Res Rev. 2022 Jan.

Abstract

Aims: This study aimed to determine whether patients with type 2 diabetes and sarcopenia had a higher risk of infection.

Study designs: A cross-sectional study and a follow-up study were performed.

Method: A total of 2562 patients were enrolled and assessed for body composition and infection status. They were classified into four groups according to body fat (BF) and muscle mass index (ASMI): obese, sarcopenic, sarcopenic obese, and normal. Among these, 275 patients were followed for a median follow-up period of 1.84 years to evaluate the relationship of changes in skeletal muscle with infection status.

Results: The sarcopenic and sarcopenic obese groups showed a higher risk of infection, an increase by 49.6% (OR = 1.496, 95% CI 1.102-2.031) and 42.4% (OR = 1.424, 95% CI 1.031-1.967) compared with the normal group, and also had a higher risk of respiratory infection, an increase by 56.0% (OR = 1.560, 95% CI 1.084-2.246) and 57.4% (OR = 1.574, 95% CI 1.080-2.293), respectively. Patients with the increased ASMI (OR = 0.079, 95% CI 0.021-0.298) represented a lower risk of infection than those with the decreased ASMI. Even a minor change (OR = 0.125, 95% CI 0.041-0.378) against age was beneficial to lowering the risk of infection. However, no association was found in the changes of body mass index and BF with infection status.

Conclusions: Sarcopenia, especially in patients with diabetes who are also obese, increases the risk of infection. Maintaining or improving muscle mass is expected to reduce infections.

Keywords: infection; obesity; sarcopenia; type 2 diabetes.

PubMed Disclaimer

References

    1. Kim EJ, Ha KH, Kim DJ, Choi YH. Diabetes and the risk of infection: a national cohort study. Diabetes Metab Journal. 2019;43(6):804-814.
    1. Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B. Impaired leucocyte functions in diabetic patients. Diabet Med. 1997;14(1):29-34.
    1. Chang FY, Shaio MF. Respiratory burst activity of monocytes from patients with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 1995;29(2):121-127.
    1. Choi JY, Yoon SJ, Kim SW, et al. Prediction of postoperative complications using multidimensional frailty score in older female cancer patients with American Society of Anesthesiologists physical status class 1 or 2. J Am Coll Surg. 2015;221(3):652-660.e652.
    1. Ferrari U, Then C, Rottenkolber M, et al. Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study. Acta Diabetol. 2020;57(9):1057-1063.

Publication types

LinkOut - more resources