Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun;51(6):842-9.
doi: 10.1136/jnnp.51.6.842.

The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type

G K Wilcock  1 , M M Esiri, D M Bowen, A O Hughes
Affiliations

The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type

G K Wilcock et al. J Neurol Neurosurg Psychiatry. 1988 Jun.

Abstract

Cell counts have been performed on cholinergic subcortical nuclei, dorsal raphe nucleus, and locus caeruleus from up to 18 cases of Alzheimer's disease and 10 age-matched control subjects. In general, the extent of cell loss in these structures was similar. In the basal nucleus the anteromedial subdivision was the least, and the posterior subdivision the most affected. A subgroup of demented subjects with Alzheimer's disease had a relatively preserved basal nucleus, and frontal lobe (CAT) choline acetyltransferase activities similar to those in control subjects, but significantly more neuronal loss in the locus caeruleus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Neuropathol Exp Neurol. 1984 Jul;43(4):359-68 - PubMed
    1. Neurosci Lett. 1985 May 1;56(1):51-5 - PubMed
    1. Psychiatr Neurol (Basel). 1966;152(2):65-103 - PubMed
    1. Ann Neurol. 1985 Jun;17(6):573-7 - PubMed
    1. Acta Neuropathol. 1985;68(3):218-23 - PubMed

Publication types

Substances