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Review
. 2021 Feb;47(1):55-64.
doi: 10.1016/j.rdc.2020.09.002. Epub 2020 Oct 29.

Understanding Risk Factors for Poor Outcomes in a Multiethnic Longitudinal Cohort: The LUMINA (Lupus in Minorities: Nature vs. Nurture) Experience (LUMINA LXXXII)

Luis Alonso González  1 , Guillermo J Pons-Estel  2 , Sergio M A Toloza  3 , Manuel Francisco Ugarte-Gil  4 , Graciela S Alarcón  5
Affiliations
Review

Understanding Risk Factors for Poor Outcomes in a Multiethnic Longitudinal Cohort: The LUMINA (Lupus in Minorities: Nature vs. Nurture) Experience (LUMINA LXXXII)

Luis Alonso González et al. Rheum Dis Clin North Am. 2021 Feb.

Abstract

The Lupus in Minorities: Nature Vs Nurture (LUMINA) cohort has placed Hispanics on the lupus map in the United States. Texan Hispanic and African American patients experience, overall, worse outcomes than the Caucasian and Puerto Rican Hispanic patients. The genetic component of ethnicity is important early in the disease course whereas socioeconomic factors become more important subsequently. The role of hydroxychloroquine in preventing damage accrual and reducing mortality in lupus patients is a major contribution of LUMINA.

Keywords: Disease activity; Disparities; Ethnicity; LUMINA; Lupus; Mortality; Quality of life; Systemic lupus erythematosus.

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