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Review
. 2021 Jul 1;39(19):2068-2078.
doi: 10.1200/JCO.21.00102. Epub 2021 May 27.

Sarcopenia in the Older Adult With Cancer

Grant R Williams  1   2 , Richard F Dunne  3 , Smith Giri  1   2 , Shlomit S Shachar  4   5 , Bette J Caan  6
Affiliations
Review

Sarcopenia in the Older Adult With Cancer

Grant R Williams et al. J Clin Oncol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Grant R. WilliamsHonoraria: Carevive Systems, Cardinal Health Richard F. DunneConsulting or Advisory Role: Exelixis Smith GiriHonoraria: CareVive, OncLiveResearch Funding: Carevive Systems, Pack Health Shlomit S. ShacharConsulting or Advisory Role: Novartis, Roche, Pfizer, LillyTravel, Accommodations, Expenses: Pfizer, RocheNo other potential conflicts of interest were reported.

Figures

FIG 1.
FIG 1.
Multifactorial causes of muscle loss in the older adult with cancer. ↑, increase; ↓, decrease.
FIG 2.
FIG 2.
Comparisons of the similarities and distinctions between sarcopenia, cachexia, and frailty. The bolded arrows indicate these are part of the formal definition of that entity. ↑, increase; ↓, decrease; ↔, can be increased, decreased, or unchanged with no real effect.
FIG 3.
FIG 3.
Hypothetical graph of the changes in muscle mass in older adults before and after a cancer diagnosis in comparison to normal age-related declines.
See this image and copyright information in PMC

References

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    1. Rolland Y, Czerwinski S, Abellan Van Kan G, et al. Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives J Nutr Health Aging 12433–4502008 - PMC - PubMed
    1. Visser M, Goodpaster BH, Kritchevsky SB, et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons J Gerontol A Biol Sci Med Sci 60324–3332005 - PubMed
    1. Janssen I, Shepard DS, Katzmarzyk PT, et al. The healthcare costs of sarcopenia in the United States J Am Geriatr Soc 5280–852004 - PubMed
    1. Heo M, Faith MS, Pietrobelli A, et al. Percentage of body fat cutoffs by sex, age, and race-ethnicity in the US adult population from NHANES 1999-2004 Am J Clin Nutr 95594–6022012 - PubMed

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