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Review
. 2021 Jul 1;39(19):2150-2163.
doi: 10.1200/JCO.21.00195. Epub 2021 May 27.

Understanding Treatment Tolerability in Older Adults With Cancer

Marie A Flannery  1 , Eva Culakova  2 , Beverly E Canin  3 , Luke Peppone  2 , Erika Ramsdale  4 , Supriya G Mohile  4
Affiliations
Review

Understanding Treatment Tolerability in Older Adults With Cancer

Marie A Flannery et al. J Clin Oncol. .
No abstract available

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Conflict of interest statement

Luke PepponeConsulting or Advisory Role: Charlotte's Web Supriya G. MohileConsulting or Advisory Role: Seattle GeneticsResearch Funding: CareviveNo other potential conflicts of interest were reported.

Figures

FIG 1.
FIG 1.
Severity of PRO-CTCAE symptoms reported by older adults with advanced cancer starting a new treatment regimen. On the basis of data from a geriatric assessment intervention trial for patients age 70 years and older receiving chemotherapy or similar agents for advanced cancer: Reducing Toxicity in Older Adults Study (n = 718). Symptoms were captured using the National Cancer Institute PRO-CTCAEs. PRO-CTCAE, Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events.
FIG 2.
FIG 2.
Distribution of the number of co-occurring PRO-CTCAE symptoms reported by older adults with advanced cancer starting a new treatment regimen. On the basis of data from a geriatric assessment intervention trial for patients age 70 years and older receiving chemotherapy or similar agents for advanced cancer: Reducing Toxicity in Older Adults Study (n = 718). Symptoms were captured using the National Cancer Institute PRO-CTCAEs. PRO-CTCAE, Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events.
FIG 3.
FIG 3.
Proposed model of treatment tolerability in older adults with cancer. ADL, activities of daily living; CTCAE, Common Terminology Criteria for Adverse Events; IADL, instrumental activities of daily living; PRO-CTCAE, Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events.
See this image and copyright information in PMC

References

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    1. Sedrak MS, Freedman RA, Cohen HJ, et al. Older adult participation in cancer clinical trials: A systematic review of barriers and interventions CA Cancer J Clin 7178–922021 - PMC - PubMed
    1. Smith BD, Smith GL, Hurria A, et al. Future of cancer incidence in the United States: Burdens upon an aging, changing nation J Clin Oncol 272758–27652009 - PubMed

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